MicroRNA‐34a promotes CMECs apoptosis and upregulate inflammatory cytokines, thus worsening CMECs damage and inhibiting angiogenesis by negatively targeting the Notch signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27433
Abstract: Recently, microRNA‐34a (miR‐34a) has been reported to lead to secretion of proinflammatory cytokine in endothelial cells, whereas whether miR‐34a plays a protective role in damaged cardiac microvascular endothelial cells (CMECs) remains to be determined. Herein,… read more here.
Keywords: angiogenesis; apoptosis; signaling pathway; microrna 34a ... See more keywords
MicroRNA-34a regulates 5-HT2C expression in dorsal raphe and contributes to the anti-depressant-like effect of fluoxetine
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108559
Abstract: Selective serotonin reuptake inhibitors (SSRIs) are designed to improve mood by raising extracellular serotonin levels through the blockade of the serotonin transporter. However, they exhibit a slow onset of action, suggesting the involvement of adaptive… read more here.
Keywords: ht2c; expression; dorsal; microrna 34a ... See more keywords
MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15877
Abstract: Current treatments for rheumatoid arthritis (RA) do not reverse underlying aberrant immune function. A genetic predisposition to RA, such as HLA-DR4 positivity, indicates that dendritic cells (DC) are of crucial importance to pathogenesis by activating… read more here.
Keywords: axl; mir 34a; 34a dependent; dendritic cells ... See more keywords
In vitro experimental study on the formation of microRNA-34a loaded exosomes and their inhibitory effect in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2070832
Abstract: ABSTRACT Studies have shown the inhibitory effect of microRNA-34a on proliferation, migration, and invasion of oral squamous cell carcinoma. However, the lack of a safe and effective delivery system limits the clinical application of microRNA-34a… read more here.
Keywords: 34a loaded; cell; oral squamous; loaded exosomes ... See more keywords
MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22597
Abstract: Purpose Human lens epithelial cell (HLEC) apoptosis is a common pathogenic mechanism in age-related cataracts (ARC). While the function of microRNAs (miRNAs) in the eye is beginning to be explored using miRNA expression array, the… read more here.
Keywords: lens epithelial; apoptosis; mir 34a; induced apoptosis ... See more keywords
Circ-DB participates in the progression of gastric cancer by competitively binding microRNA-34a to regulate the expression of MET.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201911_19552
Abstract: OBJECTIVE To figure out the possible role and mechanism of circ-DB in the pathogenesis of gastric cancer (GCa). PATIENTS AND METHODS 32 cases of postoperative GCa tissue samples and adjacent ones were collected and divided… read more here.
Keywords: expression circ; gastric cancer; binding microrna; expression ... See more keywords
Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.784044
Abstract: Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality worldwide and include a group of disorders varying from vasculature, myocardium, arrhythmias and cardiac development. MicroRNAs (miRs) are endogenous non-coding RNAs with 18–23… read more here.
Keywords: 34a cardiovascular; microrna 34a; cardiovascular diseases; 34a novel ... See more keywords
MicroRNA-34a: A Novel Therapeutic Target in Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.895242
Abstract: Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been found to play a role in… read more here.
Keywords: target; novel therapeutic; 34a novel; mir 34a ... See more keywords
Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050602
Abstract: Alopecia areata (AA) is a type of immune-mediated alopecia. Recent studies have suggested microRNAs’ (miRNAs) implication in several cellular processes, including epidermal and hair follicle biology. Single nucleotide polymorphisms (SNPs) can modify gene expression levels,… read more here.
Keywords: hair follicle; rs2666433a variant; expression; mir 34a ... See more keywords
Macrophage migration inhibitory factor serves a pivotal role in the regulation of radiation-induced cardiac senescencethrough rebalancing the microRNA-34a/sirtuin 1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2018.3838
Abstract: Radiotherapy significantly increases survival innumerous cancer patients, although it may have delayed adverse effects, including significant short‑ and long‑term effects on cardiovascular function, leading to significant morbidity and mortality. However, the mechanisms underlying these effects… read more here.
Keywords: mir 34a; senescence; mif; role ... See more keywords