Development of a reliable microRNA based electrochemical genosensor for monitoring of miR-146a, as key regulatory agent of neurodegenerative disease.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.061
Abstract: A MicroRNA (miR) based electrochemical method for quantification of miR-146a, a known biomarker for neurodegenerative disease, was developed. In this bioassay, the capture microRNA (C-miR) was self-assembled on the gold surface and used for quantification… read more here.
Keywords: neurodegenerative disease; mir 146a; mir; microrna based ... See more keywords
MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170037
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene expression. MiRNA targeting is defined by the complementarities between positions 2-8 of miRNA 5'-end with… read more here.
Keywords: delivery; target; microrna based; therapeutics cardiovascular ... See more keywords
Development of circulating microRNA-based biomarkers for medical decision-making: a friendly reminder of what should NOT be done
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2022.2128030
Abstract: Abstract Circulating cell-free microRNAs (miRNAs) represent a major reservoir for biomarker discovery. Unfortunately, their implementation in clinical practice is limited due to a profound lack of reproducibility. The great technical variability linked to major pre-analytical… read more here.
Keywords: circulating microrna; development circulating; microrna based; mirna quantification ... See more keywords
The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00496-7
Abstract: Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their… read more here.
Keywords: promise microrna; alzheimer disease; based therapies; microrna based ... See more keywords
microRNA-based genetic therapy in leukemia: properties, delivery, and experimental models
Sign Up to like & getrecommendations! Published in 2023 at "Current Gene Therapy"
DOI: 10.2174/1566523223666230426153622
Abstract: Leukemia is a type of cancer that affects white blood cells. In this disease, immature blood cells undergo genetic mutations, leading to excessive replication and reduced cell death compared to healthy cells. In cancer, there… read more here.
Keywords: leukemia; therapy; gene therapy; microrna based ... See more keywords
microRNA-Based Biomarkers in Lung Cancer: Recent Advances and potential Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/2772432817666220520085719
Abstract: INTRODUCTION MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that post-transcriptionally control the expression of genes by binding and degrading their target mRNAs. miRNAs can function as possible tumor suppressors or oncogenes in… read more here.
Keywords: lung cancer; cancer recent; biomarkers lung; based biomarkers ... See more keywords
microRNA-Based Network and Pathway Analysis for Neuropathic Pain in Rodent Models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.780730
Abstract: Neuropathic pain (NP) is poorly managed, and in-depth mechanisms of gene transcriptome alterations in NP pathogenesis are not yet fully understood. To determine microRNA-related molecular mechanisms of NP and their transcriptional regulation in NP, PubMed,… read more here.
Keywords: microrna based; analysis; neuropathic pain; based network ... See more keywords
MicroRNA-Based Diagnosis and Therapeutics for Vascular Cognitive Impairment and Dementia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.895316
Abstract: Vascular cognitive impairment and dementia (VCID) is a neurodegenerative disease that is recognized as the second leading cause of dementia after Alzheimer's disease (AD). The underlying pathological mechanism of VCID include crebromicrovascular dysfunction, blood-brain barrier… read more here.
Keywords: microrna based; vascular cognitive; cognitive impairment; impairment dementia ... See more keywords
microRNA-Based Biomarkers in Alzheimer’s Disease (AD)
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.585432
Abstract: Alzheimer’s disease (AD) is a multifactorial, age-related neurological disease characterized by complex pathophysiological dynamics taking place at multiple biological levels, including molecular, genetic, epigenetic, cellular and large-scale brain networks. These alterations account for multiple pathophysiological… read more here.
Keywords: alzheimer disease; based biomarkers; microrna based; disease ... See more keywords
Genome-Wide Development of MicroRNA-Based SSR Markers in Medicago truncatula with Their Transferability Analysis and Utilization in Related Legume Species
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18112440
Abstract: Microsatellite (simple sequence repeats, SSRs) marker is one of the most widely used markers in marker-assisted breeding. As one type of functional markers, MicroRNA-based SSR (miRNA-SSR) markers have been exploited mainly in animals, but the… read more here.
Keywords: based ssr; mirna ssr; microrna based; transferability ... See more keywords
MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20225600
Abstract: Myotonic dystrophy involves two types of chronically debilitating rare neuromuscular diseases: type 1 (DM1) and type 2 (DM2). Both share similarities in molecular cause, clinical signs, and symptoms with DM2 patients usually displaying milder phenotypes.… read more here.
Keywords: therapeutic perspectives; dystrophy; microrna based; mis regulation ... See more keywords