Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00945
Abstract: The identification of small molecules that bind to and perturb the function of microRNAs is an attractive approach for the treatment for microRNA-associated pathologies. However, there are only a few small molecules known to interact… read more here.
Keywords: molecule; inhibitors microrna; small molecule; small molecules ... See more keywords
Abstract PR01: Three-hit model of Wilms’ tumor formation reveals immunogenic transcriptional subtypes
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-pr01
Abstract: Wilms’ tumor is the most common kidney cancer in children. Despite advances in care, children with metastatic, anaplastic, or relapsed disease still fare poorly. Recent studies have uncovered novel types of driver mutations, including in… read more here.
Keywords: wilms tumor; three hit; tumor formation; microrna processing ... See more keywords
The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.991347
Abstract: We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for central B cell maturation. To determine whether miRNA processing… read more here.
Keywords: cell; dgcr8 required; microrna processing; response ... See more keywords
Steroidal Regulation of Oviductal microRNAs Is Associated with microRNA-Processing in Beef Cows
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DOI: 10.3390/ijms22020953
Abstract: Information on molecular mechanisms through which sex-steroids regulate oviductal function to support early embryo development is lacking. Here, we hypothesized that the periovulatory endocrine milieu affects the miRNA processing machinery and miRNA expression in bovine… read more here.
Keywords: oviductal micrornas; micrornas associated; steroidal regulation; associated microrna ... See more keywords