Five EMT‐related genes signature predicts overall survival and immune environment in microsatellite instability‐high gastric cancer
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DOI: 10.1002/cam4.4975
Abstract: Microsatellite instability‐high (MSI‐H) subgroup of gastric cancer (GC) is characterized by a high tumor mutational burden, increased lymphocytic infiltration, and enhanced inflammatory cytokines. GC patients with MSI‐H status have a good response to immune checkpoint… read more here.
Keywords: microsatellite instability; instability high; gastric cancer; immune ... See more keywords
Implementation of microsatellite instability testing for the assessment of solid tumors in clinical practice
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DOI: 10.1002/cam4.5569
Abstract: In Japan, microsatellite instability (MSI) testing for solid tumors was introduced in clinical practice in December 2018. Although immune checkpoint inhibitors (ICIs) are established standards of care for patients with MSI‐high tumors, the status of… read more here.
Keywords: practice; microsatellite instability; implementation microsatellite; clinical practice ... See more keywords
Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses
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DOI: 10.1002/ijc.33322
Abstract: Microsatellite instability (MSI) is categorized by mutation frequency: high MSI (MSI‐H), low MSI (MSI‐L) and microsatellite stable (MSS). MSI‐H tumors have a distinct immunogenic phenotype, with immunotherapies using checkpoint inhibitors already approved for the treatment… read more here.
Keywords: msi; msi tumors; mss; microsatellite instability ... See more keywords
Phase II study of durvalumab monotherapy in patients with previously treated microsatellite instability‐high/mismatch repair‐deficient or POLE‐mutated metastatic or unresectable colorectal cancer
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DOI: 10.1002/ijc.33966
Abstract: The aim of our study is to evaluate the clinical efficacy of durvalumab in patients with microsatellite instability‐high/mismatch repair‐deficient (MSI‐H/dMMR) or polymerase epsilon (POLE)‐mutated metastatic or unresectable colorectal cancer (mCRC) who had disease progression after… read more here.
Keywords: microsatellite instability; study; response; cancer ... See more keywords
Genomic landscape of microsatellite instability in Chinese tumors: A comparison of Chinese and TCGA cohorts
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DOI: 10.1002/ijc.34119
Abstract: Microsatellite instability (MSI) is an important biomarker for predicting the response to immunotherapy and prognosis that mainly results from a defective DNA mismatch repair (MMR) system and strongly correlates with high tumor mutation burden (TMB).… read more here.
Keywords: msi; microsatellite instability; genomic landscape; instability ... See more keywords
Noninvasive detection of microsatellite instability in patients with endometrial cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34435
Abstract: The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating‐DNA (cfDNA) samples capture the intratumor… read more here.
Keywords: endometrial cancer; microsatellite instability; analysis; msi ... See more keywords
Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28287
Abstract: Microsatellite instability (MSI), caused by mismatch repair (MMR) protein defects that lead to uncorrectable mismatch bases, results in the accumulation of gene mutations and ultimately to tumors. Preoperative prediction of MSI can provide a basis… read more here.
Keywords: proton transfer; endometrial cancer; microsatellite instability; amide proton ... See more keywords
Gastric cancer with microsatellite instability displays increased thymidylate synthase expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26822
Abstract: Gastric cancer (GC) with microsatellite instability (MSI) is a less aggressive disease and associated with resistance to 5‐fluorouracil (5‐FU)‐based chemotherapy (CMT). Thymidylate synthase (TS) is inhibited by 5‐FU, and another potential mediator of therapeutic resistance… read more here.
Keywords: cancer microsatellite; microsatellite instability; thymidylate synthase; gastric cancer ... See more keywords
Deep learning image analysis quantifies tumor heterogeneity and identifies microsatellite instability in colon cancer
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DOI: 10.1002/jso.27118
Abstract: Deep learning utilizing convolutional neural networks (CNNs) applied to hematoxylin & eosin (H&E)‐stained slides numerically encodes histomorphological tumor features. Tumor heterogeneity is an emerging biomarker in colon cancer that is, captured by these features, whereas… read more here.
Keywords: tumor heterogeneity; colon cancer; microsatellite instability; deep learning ... See more keywords
Targeting Colon Cancers with Mutated BRAF and Microsatellite Instability.
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DOI: 10.1007/978-3-030-02771-1_2
Abstract: The subgroup of colon cancer (CRC) characterized by mutation in the BRAF gene and high mutation rate in the genomic DNA sequence, known as the microsatellite instability (MSI) phenotype, accounts for roughly 10% of the… read more here.
Keywords: colon cancers; targeting colon; colon; microsatellite instability ... See more keywords
Detection of microsatellite instability with Idylla MSI assay in colorectal and endometrial cancer
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DOI: 10.1007/s00428-021-03082-w
Abstract: Universal testing of microsatellite instability (MSI) is recommended for colorectal cancer (CRC) and endometrial cancer (EC) to screen for Lynch syndrome and to aid in assessing prognosis and optimal treatment. We compared the performance of… read more here.
Keywords: test; idylla; endometrial cancer; microsatellite instability ... See more keywords