Five EMT‐related genes signature predicts overall survival and immune environment in microsatellite instability‐high gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4975
Abstract: Microsatellite instability‐high (MSI‐H) subgroup of gastric cancer (GC) is characterized by a high tumor mutational burden, increased lymphocytic infiltration, and enhanced inflammatory cytokines. GC patients with MSI‐H status have a good response to immune checkpoint… read more here.
Keywords: microsatellite instability; instability high; gastric cancer; immune ... See more keywords
Implementation of microsatellite instability testing for the assessment of solid tumors in clinical practice
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5569
Abstract: In Japan, microsatellite instability (MSI) testing for solid tumors was introduced in clinical practice in December 2018. Although immune checkpoint inhibitors (ICIs) are established standards of care for patients with MSI‐high tumors, the status of… read more here.
Keywords: practice; microsatellite instability; implementation microsatellite; clinical practice ... See more keywords
Gene mutation profiling in microsatellite instability colorectal cancer and its association with the efficacy of immunotherapy: A retrospective study
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.6910
Abstract: Microsatellite instability‐high (MSI‐H) colorectal cancer (CRC) is known for its heightened responsiveness to immunotherapy. However, establishing robust predictive markers for immunotherapy efficacy remains imperative. This retrospective study aimed to elucidate the genetic landscape of MSI‐H… read more here.
Keywords: colorectal cancer; cancer; immunotherapy; microsatellite instability ... See more keywords
A prediction model based on deep learning and radiomics features of DWI for the assessment of microsatellite instability in endometrial cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70046
Abstract: To explore the efficacy of a prediction model based on diffusion‐weighted imaging (DWI) features extracted from deep learning (DL) and radiomics combined with clinical parameters and apparent diffusion coefficient (ADC) values to identify microsatellite instability… read more here.
Keywords: deep learning; cancer; model based; learning radiomics ... See more keywords
Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33322
Abstract: Microsatellite instability (MSI) is categorized by mutation frequency: high MSI (MSI‐H), low MSI (MSI‐L) and microsatellite stable (MSS). MSI‐H tumors have a distinct immunogenic phenotype, with immunotherapies using checkpoint inhibitors already approved for the treatment… read more here.
Keywords: msi; msi tumors; mss; microsatellite instability ... See more keywords
Phase II study of durvalumab monotherapy in patients with previously treated microsatellite instability‐high/mismatch repair‐deficient or POLE‐mutated metastatic or unresectable colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33966
Abstract: The aim of our study is to evaluate the clinical efficacy of durvalumab in patients with microsatellite instability‐high/mismatch repair‐deficient (MSI‐H/dMMR) or polymerase epsilon (POLE)‐mutated metastatic or unresectable colorectal cancer (mCRC) who had disease progression after… read more here.
Keywords: microsatellite instability; study; response; cancer ... See more keywords
Genomic landscape of microsatellite instability in Chinese tumors: A comparison of Chinese and TCGA cohorts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34119
Abstract: Microsatellite instability (MSI) is an important biomarker for predicting the response to immunotherapy and prognosis that mainly results from a defective DNA mismatch repair (MMR) system and strongly correlates with high tumor mutation burden (TMB).… read more here.
Keywords: msi; microsatellite instability; genomic landscape; instability ... See more keywords
Noninvasive detection of microsatellite instability in patients with endometrial cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34435
Abstract: The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating‐DNA (cfDNA) samples capture the intratumor… read more here.
Keywords: endometrial cancer; microsatellite instability; analysis; msi ... See more keywords
Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28287
Abstract: Microsatellite instability (MSI), caused by mismatch repair (MMR) protein defects that lead to uncorrectable mismatch bases, results in the accumulation of gene mutations and ultimately to tumors. Preoperative prediction of MSI can provide a basis… read more here.
Keywords: proton transfer; endometrial cancer; microsatellite instability; amide proton ... See more keywords
Gastric cancer with microsatellite instability displays increased thymidylate synthase expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26822
Abstract: Gastric cancer (GC) with microsatellite instability (MSI) is a less aggressive disease and associated with resistance to 5‐fluorouracil (5‐FU)‐based chemotherapy (CMT). Thymidylate synthase (TS) is inhibited by 5‐FU, and another potential mediator of therapeutic resistance… read more here.
Keywords: cancer microsatellite; microsatellite instability; thymidylate synthase; gastric cancer ... See more keywords
Deep learning image analysis quantifies tumor heterogeneity and identifies microsatellite instability in colon cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27118
Abstract: Deep learning utilizing convolutional neural networks (CNNs) applied to hematoxylin & eosin (H&E)‐stained slides numerically encodes histomorphological tumor features. Tumor heterogeneity is an emerging biomarker in colon cancer that is, captured by these features, whereas… read more here.
Keywords: tumor heterogeneity; colon cancer; microsatellite instability; deep learning ... See more keywords