Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.004
Abstract: Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous… read more here.
Keywords: microsomal prostaglandin; prostaglandin synthase; synthase; contact hypersensitivity ... See more keywords
Downregulation of microsomal prostaglandin E synthase-1 (mPGES-1) expression in chondrocytes is regulated by MAP kinase phosphatase-1 (MKP-1).
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.03.014
Abstract: OBJECTIVES Microsomal prostaglandin E synthase-1 (mPGES-1) catalyses the formation of PGE2 in inflammatory tissues. It is considered a potential drug target in inflammatory conditions to achieve clinical benefits comparable to NSAIDs with a better tolerability.… read more here.
Keywords: microsomal prostaglandin; mkp; expression; mpges expression ... See more keywords
Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1344218
Abstract: ABSTRACT Introduction: Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes the terminal step of prostaglandin E2 (PGE2) generation. It is strongly upregulated in inflamed tissues and overexpressed in tumors and it has been recognized as a key… read more here.
Keywords: microsomal prostaglandin; prostaglandin synthase; inflammatory; mpges inhibitors ... See more keywords
The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac137
Abstract: AIMS Microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E2 (PGE2) induces angiogenesis through the prostaglandin E2 receptor (EP1-4). Among immune cells, regulatory T cells (Tregs), which inhibit immune responses, have been implicated in angiogenesis, and PGE2 is… read more here.
Keywords: ischemia; regulatory cells; prostaglandin synthase; recovery ischemia ... See more keywords
Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodeling after myocardial infarction in mice.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16061
Abstract: BACKGROUND Heart failure with reduced ejection fraction (HFrEF) is a major consequence of myocardial infarction (MI). We have previously demonstrated that the microsomal prostaglandin E synthase-1 (mPGES-1)/PGE2 pathway constrains reperfusion injury after acute myocardial ischemia.… read more here.
Keywords: inhibition; myocardial infarction; adverse cardiac; prostaglandin synthase ... See more keywords
Computer-Aided Drug Design of Anti-inflammatory Agents Targeting Microsomal Prostaglandin E2 Synthase-1 (mPGES-1).
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220317122948
Abstract: Inflammation is a natural process in response to external stimuli associated with organism protection. However, this reaction could be exaggerated, leading to severe damages related to physiopathological processes, such as rheumatoid arthritis, cancer, diabetes, allergies,… read more here.
Keywords: anti inflammatory; microsomal prostaglandin; drug design;
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "AntiCancer Research"
DOI: 10.21873/anticanres.14888
Abstract: Background/Aim: Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) is a terminal enzyme in PGE2 synthesis and highly expressed in several cancers. In this study, to reveal the involvement of mPGES-1 in skin carcinogenesis, the effect of… read more here.
Keywords: microsomal prostaglandin; skin carcinogenesis; prostaglandin synthase; induced skin ... See more keywords
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113647
Abstract: Microsomal prostaglandin E synthetase-1 (mPGES-1) is an inducible terminal enzyme for the production of prostaglandin E2 (PGE2). In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, mPGES-1 is induced in vascular endothelial cells… read more here.
Keywords: microsomal prostaglandin; prostaglandin; endothelial interleukin; prostaglandin synthetase ... See more keywords
Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033049
Abstract: Nonalcoholic fatty liver disease (NAFLD) affects a substantial proportion of the general population and is even more prevalent in obese and diabetic patients. NAFLD, and particularly the more advanced manifestation of the disease, nonalcoholic steatohepatitis… read more here.
Keywords: microsomal prostaglandin; liver disease; prostaglandin synthase; fatty liver ... See more keywords