In Silico Prediction of Human and Rat Liver Microsomal Stability via Machine Learning Methods.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00207
Abstract: Liver microsomal stability is an important property considered for the screening of drug candidates in the early stage of drug development. Determination of hepatic metabolic stability can be performed by an in vitro assay, but… read more here.
Keywords: machine learning; learning methods; stability; microsomal stability ... See more keywords
New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4221731
Abstract: The increasing number of Plasmodium falciparum strains resistant to current treatments justifies the urgent need to discover new compounds active on several stages of the parasite development. Based on the structure of Gamhepathiopine, a 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one… read more here.
Keywords: new antiplasmodial; microsomal stability; amino; intestinal permeability ... See more keywords