Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25781
Abstract: Older AML patients have low remission rates and poor survival outcomes with standard chemotherapy. Microtransplantation (MST) refers to infusion of allogeneic hematopoietic stem cells without substantial engraftment. MST has been shown to improve clinical outcomes… read more here.
Keywords: chemotherapy; microtransplantation; aml patients; mst ... See more keywords
Current state of nonengrafting donor leukocyte infusion (focus on microtransplantation for acute myeloid leukemia).
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000539
Abstract: PURPOSE OF REVIEW Microtransplantation (or micro-stem cell transplantation, MST) is one permutation of alloreactive immunotherapy increasingly studied in clinical trials. It is most commonly applied to patients with myeloid malignancies who are not suitable candidates… read more here.
Keywords: myeloid leukemia; acute myeloid; leukocyte infusion; nonengrafting donor ... See more keywords
Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers.
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DOI: 10.2174/1389450116666150304103849
Abstract: "Alloreactive cell therapy without substantial engraftment"; (ACT-WiSE) refers to adoptive transfer of natural ("non-engineered") human leukocyte antigen-mismatched lymphocytes to mediate anti-neoplastic alloreactivity in recipients without employing pharmacologic immunosuppression. By definition, ACT-WiSE entails subsequent rejection of… read more here.
Keywords: donor; cell; microtransplantation; act wise ... See more keywords