The gamma‐tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100114
Abstract: Microtubules are protein cylinders with functions in cell motility, signal sensing, cell organization, intracellular transport, and chromosome segregation. One of the key properties of microtubules is their dynamic architecture, allowing them to grow and shrink… read more here.
Keywords: microtubule; tubulin ring; ring complex; organization ... See more keywords
Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21355
Abstract: Neurons are highly differentiated cells responsible for the conduction and transmission of information in the nervous system. The proper function of a neuron relies on the compartmentalization of their intracellular domains. Differentiated neuroblastoma cells have… read more here.
Keywords: microtubule; regulating proteins; microtubule regulating; n1e 115 ... See more keywords
A model for the catalytic activity of microtubule polymerases
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21734
Abstract: A XMAP215/Stu2/Alp14 polymerase can catalyze processively the tubulin addition to the microtubule (MT) plus end. In this work, a model is proposed for the underlying molecular mechanism of the polymerase activity, where the polymerase can… read more here.
Keywords: activity microtubule; catalytic activity; model; microtubule ... See more keywords
Synthesis and evaluation of 2‐aryl‐1H‐benzo[d]imidazole derivatives as potential microtubule targeting agents
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21909
Abstract: Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de‐polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidate. Here,… read more here.
Keywords: microtubule targeting; benzo imidazole; imidazole derivatives; microtubule ... See more keywords
ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24599
Abstract: Classical microtubule‐associated proteins (MAPs) were originally identified based on their co‐purification with microtubules assembled from mammalian brain lysate. They have since been found to perform a range of functions involved in regulating the dynamics of… read more here.
Keywords: microtubule; microtubule associated; associated proteins; remapping microtubule ... See more keywords
Alleles of unc‐33/CRMP exhibit defects during Caenorhabditis elegans epidermal morphogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.497
Abstract: Microtubule‐associated proteins regulate the dynamics, organization, and function of microtubules, impacting a number of vital cellular processes. CRMPs have been shown to control microtubule assembly and axon outgrowth during neuronal differentiation. While many microtubule‐associated proteins… read more here.
Keywords: crmp exhibit; alleles unc; unc crmp; defects caenorhabditis ... See more keywords
Regulators of spindle microtubules and their mechanisms: Living together matters
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1708
Abstract: Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through… read more here.
Keywords: microtubule; kinetochore microtubule; mechanisms living; microtubules mechanisms ... See more keywords
DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29690
Abstract: Angiogenesis and vasculogenic mimicry (VM) are the main causes of tumor metastasis and recurrence. In this study, we investigated the antiangiogenesis and anti‐VM formation of a novel microtubule depolymerizing agent, DHPAC, as well as combretastatin… read more here.
Keywords: microtubule; dhpac; angiogenesis vasculogenic; formation ... See more keywords
Profilin—A master coordinator of actin and microtubule organization in mammalian cells
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DOI: 10.1002/jcp.30379
Abstract: The last two decades have witnessed a tremendous increase in cell biology data. Not least is this true for studies of the dynamic organization of the microfilament and microtubule systems in animal cells where analyses… read more here.
Keywords: microtubule; profilin master; master coordinator; organization ... See more keywords
Organization of cortical microtubules in differentiated cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31011
Abstract: The microtubule cytoskeleton plays a critical role in a variety of cellular activities, and its structures and functions have been extensively studied. However, little is known about cell differentiation-related microtubule remodeling, its regulatory mechanisms, and… read more here.
Keywords: differentiated cells; cell differentiation; organization cortical; microtubule ... See more keywords
Insights into allosteric control of microtubule dynamics from a buried β‐tubulin mutation that causes faster growth and slower shrinkage
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3842
Abstract: αβ‐tubulin subunits cycle through a series of different conformations in the polymer lattice during microtubule growing and shrinking. How these allosteric responses to different tubulin:tubulin contacts contribute to microtubule dynamics, and whether the contributions are… read more here.
Keywords: microtubule; allosteric control; microtubule dynamics; tubulin ... See more keywords