The gamma‐tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100114
Abstract: Microtubules are protein cylinders with functions in cell motility, signal sensing, cell organization, intracellular transport, and chromosome segregation. One of the key properties of microtubules is their dynamic architecture, allowing them to grow and shrink… read more here.
Keywords: microtubule; tubulin ring; ring complex; organization ... See more keywords
Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21355
Abstract: Neurons are highly differentiated cells responsible for the conduction and transmission of information in the nervous system. The proper function of a neuron relies on the compartmentalization of their intracellular domains. Differentiated neuroblastoma cells have… read more here.
Keywords: microtubule; regulating proteins; microtubule regulating; n1e 115 ... See more keywords
A model for the catalytic activity of microtubule polymerases
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DOI: 10.1002/cm.21734
Abstract: A XMAP215/Stu2/Alp14 polymerase can catalyze processively the tubulin addition to the microtubule (MT) plus end. In this work, a model is proposed for the underlying molecular mechanism of the polymerase activity, where the polymerase can… read more here.
Keywords: activity microtubule; catalytic activity; model; microtubule ... See more keywords
Ionic strength alters crosslinker‐driven self‐organization of microtubules
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DOI: 10.1002/cm.21839
Abstract: The microtubule cytoskeleton is a major structural element inside cells that directs self‐organization using microtubule‐associated proteins and motors. It has been shown that finite‐sized, spindle‐like microtubule organizations, called “tactoids,” can form in vitro spontaneously from… read more here.
Keywords: ionic strength; map65; self organization; microtubule ... See more keywords
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts.
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DOI: 10.1002/cm.22034
Abstract: A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types. Targeting… read more here.
Keywords: egg extracts; tpx2 regulates; tpx2; xenopus egg ... See more keywords
Noncentrosomal Microtubule Assembly and Its Regulation.
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DOI: 10.1002/cm.70006
Abstract: Microtubule nucleation is a critical initiating step in microtubule assembly during the cell cycle. This fundamental process is primarily mediated by γ-tubulin-containing complexes, namely, the γ-tubulin small complex (γ-TuSC) and its higher-order assembly, the γ-tubulin… read more here.
Keywords: noncentrosomal microtubule; microtubule; microtubule assembly; assembly regulation ... See more keywords
Tau Protein and Tauopathies: Exploring Tau Protein–Protein and Microtubule Interactions, Cross‐Interactions and Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400180
Abstract: Tau, a microtubule‐associated protein (MAP), is essential to maintaining neuronal stability and function in the healthy brain. However, aberrant modifications and pathological aggregations of Tau are implicated in various neurodegenerative disorders, collectively known as tauopathies.… read more here.
Keywords: tau protein; therapeutic strategies; protein; protein protein ... See more keywords
Synthesis and evaluation of 2‐aryl‐1H‐benzo[d]imidazole derivatives as potential microtubule targeting agents
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21909
Abstract: Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de‐polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidate. Here,… read more here.
Keywords: microtubule targeting; benzo imidazole; imidazole derivatives; microtubule ... See more keywords
ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24599
Abstract: Classical microtubule‐associated proteins (MAPs) were originally identified based on their co‐purification with microtubules assembled from mammalian brain lysate. They have since been found to perform a range of functions involved in regulating the dynamics of… read more here.
Keywords: microtubule; microtubule associated; associated proteins; remapping microtubule ... See more keywords
Alleles of unc‐33/CRMP exhibit defects during Caenorhabditis elegans epidermal morphogenesis
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DOI: 10.1002/dvdy.497
Abstract: Microtubule‐associated proteins regulate the dynamics, organization, and function of microtubules, impacting a number of vital cellular processes. CRMPs have been shown to control microtubule assembly and axon outgrowth during neuronal differentiation. While many microtubule‐associated proteins… read more here.
Keywords: crmp exhibit; alleles unc; unc crmp; defects caenorhabditis ... See more keywords
Regulators of spindle microtubules and their mechanisms: Living together matters
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DOI: 10.1002/iub.1708
Abstract: Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through… read more here.
Keywords: microtubule; kinetochore microtubule; mechanisms living; microtubules mechanisms ... See more keywords