Microtubule Acetylation Is Required for Mechanosensation in Drosophila.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.075
Abstract: At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown, although prior studies have shown… read more here.
Keywords: drosophila; microtubule; acetylation; acetylation required ... See more keywords
Causes and Consequences of Microtubule Acetylation
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.10.044
Abstract: Among the different types of cytoskeletal components, microtubules arguably accumulate the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) of α-tubulin has received particular attention because it is the only tubulin PTM… read more here.
Keywords: acetylation; consequences microtubule; biology; causes consequences ... See more keywords
Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and cells"
DOI: 10.14348/molcells.2023.2192
Abstract: Microtubule acetylation has been proposed as a marker of highly heterogeneous and aggressive triple-negative breast cancer (TNBC). The novel microtubule acetylation inhibitors GM-90257 and GM-90631 (GM compounds) cause TNBC cancer cell death but the underlying… read more here.
Keywords: cell death; microtubule acetylation; death; jnk ... See more keywords