Microtubule Attachment and Centromeric Tension Shape the Protein Architecture of the Human Kinetochore
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.09.038
Abstract: The nanoscale protein architecture of the kinetochore plays an integral role in specifying the mechanisms underlying its functions in chromosome segregation. However, defining this architecture in human cells remains challenging because of the large size… read more here.
Keywords: kinetochore; architecture human; microtubule attachment; protein architecture ... See more keywords
Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260226
Abstract: Mitotic cell division requires that kinetochores form microtubule attachments that can segregate chromosomes and control mitotic progression via the spindle assembly checkpoint. During prometaphase, kinetochores shed a domain called the fibrous corona as microtubule attachments… read more here.
Keywords: corona; microtubule attachment; microtubule; dynein ... See more keywords