Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.04.013
Abstract: During cell division, genome inheritance is orchestrated by microtubule attachments formed at kinetochores of mitotic chromosomes. The primary microtubule coupler at the kinetochore, the Ndc80 complex, is regulated by Aurora kinase phosphorylation of its N-terminal… read more here.
Keywords: kinetochore microtubule; ndc80 tail; microtubule attachments; tail ... See more keywords
Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.36392
Abstract: Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions. Here, we present a method, based on fluorescence lifetime imaging… read more here.
Keywords: tension; kinetochore microtubule; microtubule attachments; ndc80 binding ... See more keywords