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   Articles with "microtubule dynamics" as a keyword



Insights into allosteric control of microtubule dynamics from a buried β‐tubulin mutation that causes faster growth and slower shrinkage

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recommendations! Published in 2020 at "Protein Science"

DOI: 10.1002/pro.3842

Abstract: αβ‐tubulin subunits cycle through a series of different conformations in the polymer lattice during microtubule growing and shrinking. How these allosteric responses to different tubulin:tubulin contacts contribute to microtubule dynamics, and whether the contributions are… read more here.

Keywords: microtubule; allosteric control; microtubule dynamics; tubulin ... See more keywords
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Stochastic Model of Microtubule Dynamics

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recommendations! Published in 2017 at "Journal of Statistical Physics"

DOI: 10.1007/s10955-017-1855-2

Abstract: We introduce a continuous time stochastic process on strings made of two types of particle, whose dynamics mimics that of microtubules in a living cell. The long term behaviour of the system is described in… read more here.

Keywords: model; model microtubule; stochastic model; microtubule dynamics ... See more keywords

A TIRF microscopy assay to decode how tau regulates EB's tracking at microtubule ends.

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recommendations! Published in 2017 at "Methods in cell biology"

DOI: 10.1016/bs.mcb.2017.06.013

Abstract: Tau is a major microtubule-associated protein (MAP) mainly expressed in the brain. Tau binds the lattice of microtubules and favors their elongation and bundling. Recent studies have shown that tau is also a partner of… read more here.

Keywords: microtubule ends; tau; microscopy; microtubule dynamics ... See more keywords

Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin

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recommendations! Published in 2019 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2019.01.023

Abstract: Graphical abstract Figure. No caption available. &NA; Crocin, a constituent of the saffron spice, exhibits promising antitumor activity in animal models and also inhibits the proliferation of several types of cancer cells in culture. Recently,… read more here.

Keywords: microtubule; spindle microtubule; microtubule dynamics; crocin ... See more keywords

Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics.

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recommendations! Published in 2022 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2022.105700

Abstract: We recently reported a new class of imidazole-based chalcones as potential antimitotic agents. In view of their promising cytotoxic activity, a comprehensive structure-activity relationship (SAR) of these compounds was undertaken focusing on four major structural… read more here.

Keywords: pharmacophore optimization; chalcones modulate; microtubule dynamics; optimization imidazole ... See more keywords

Intrinsically Defective Microtubule Dynamics Contribute to Age-Related Chromosome Segregation Errors in Mouse Oocyte Meiosis-I

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recommendations! Published in 2017 at "Current Biology"

DOI: 10.1016/j.cub.2017.02.025

Abstract: Chromosome segregation errors in mammalian oocytes compromise development and are particularly prevalent in older females, but the aging-related cellular changes that promote segregation errors remain unclear [1, 2]. Aging causes a loss of meiotic chromosome… read more here.

Keywords: microtubule dynamics; chromosome; segregation errors; age related ... See more keywords
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The Tubulin Code in Microtubule Dynamics and Information Encoding.

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recommendations! Published in 2020 at "Developmental cell"

DOI: 10.1016/j.devcel.2020.06.008

Abstract: Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton. Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin isoforms and post-translational modifications, a "tubulin code," which is thought to support… read more here.

Keywords: tubulin; tubulin code; microtubule dynamics; code microtubule ... See more keywords

Proteomic analysis of human iPSC-derived sensory neurons implicates cell stress and microtubule dynamics dysfunction in bortezomib-induced peripheral neurotoxicity

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recommendations! Published in 2021 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113520

Abstract: The neurotoxic effects of the chemotherapeutic agent bortezomib on dorsal root ganglia sensory neurons are well documented, yet the mechanistic underpinnings that govern these cellular processes remain incompletely understood. In this study, system-wide proteomic changes… read more here.

Keywords: derived sensory; bortezomib; microtubule dynamics; sensory neurons ... See more keywords
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Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2019.04.120

Abstract: In specialized cell types such as neurons, microtubules maintain the integrity of axons by forming stable bundles and facilitate the transport of synaptic vesicles. The cells regulate the stability and dynamics of microtubules using a… read more here.

Keywords: neuronal microtubule; tau implications; regulation neuronal; microtubule dynamics ... See more keywords

TUBright: A Peptide Probe for Imaging Microtubules.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c01285

Abstract: In vitro assays using reconstituted microtubules have provided molecular insights into the principles of microtubule dynamics and the roles of microtubule-associated proteins. Emerging questions that further uncover the complexity in microtubule dynamics, especially those on… read more here.

Keywords: imaging microtubules; probe imaging; microtubule dynamics; peptide probe ... See more keywords

Inhibition of Microtubule Dynamics in Cancer Cells by Indole-Modified Latonduine Derivatives and Their Metal Complexes

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recommendations! Published in 2022 at "Inorganic Chemistry"

DOI: 10.1021/acs.inorgchem.1c03154

Abstract: Indolo[2,3-d]benzazepines (indololatonduines) are rarely discussed in the literature. In this project, we prepared a series of novel indololatonduine derivatives and their RuII and OsII complexes and investigated their microtubule-targeting properties in comparison with paclitaxel and… read more here.

Keywords: cancer cells; microtubule dynamics; microtubule; metal ... See more keywords