Optical Tweezers-Based Measurements of Forces and Dynamics at Microtubule Ends.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6421-5_16
Abstract: Microtubules are dynamic cytoskeletal polymers that polymerize and depolymerize while interacting with different proteins and structures within the cell. The highly regulated dynamic properties as well as the pushing and pulling forces generated by dynamic… read more here.
Keywords: tweezers based; microtubule ends; optical tweezers; forces dynamics ... See more keywords
A TIRF microscopy assay to decode how tau regulates EB's tracking at microtubule ends.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2017.06.013
Abstract: Tau is a major microtubule-associated protein (MAP) mainly expressed in the brain. Tau binds the lattice of microtubules and favors their elongation and bundling. Recent studies have shown that tau is also a partner of… read more here.
Keywords: microtubule ends; tau; microscopy; microtubule dynamics ... See more keywords
Distinguishing synaptic vesicle precursor navigation of microtubule ends with a single rate constant model
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82836-7
Abstract: Axonal motor driven cargo utilizes the microtubule cytoskeleton in order to direct cargo, such as synaptic vesicle precursors (SVP), to where they are needed. This transport requires vesicles to travel up to microns in distance.… read more here.
Keywords: microtubule ends; microtubule; vesicle; model ... See more keywords
Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.48117
Abstract: The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 has been attributed to high-affinity… read more here.
Keywords: eb1; microtubule; facilitates tip; growing microtubule ... See more keywords