Molecular mechanisms underlying microtubule growth dynamics
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.02.035
Abstract: Microtubules are dynamic cytoskeletal filaments composed of αβ-tubulin heterodimers. Historically, the dynamics of single tubulin interactions at the growing microtubule tip have been inferred from steady-state growth kinetics. However, recent advances in the production of… read more here.
Keywords: microtubule; microtubule growth; tubulin tubulin; tubulin interactions ... See more keywords
Taxanes convert regions of perturbed microtubule growth into rescue sites
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DOI: 10.1038/s41563-019-0546-6
Abstract: Microtubules are polymers of tubulin dimers, and conformational transitions in the microtubule lattice drive microtubule dynamic instability and affect various aspects of microtubule function. The exact nature of these transitions and their modulation by anticancer… read more here.
Keywords: convert regions; microtubule; microtubule growth; regions perturbed ... See more keywords
Dynamic balance between vesicle transport and microtubule growth enables neurite outgrowth
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006877
Abstract: Whole cell responses involve multiple subcellular processes (SCPs). To understand how balance between SCPs controls the dynamics of whole cell responses we studied neurite outgrowth in rat primary cortical neurons in culture. We used a… read more here.
Keywords: whole cell; microtubule growth; neurite outgrowth; growth ... See more keywords