Microtubule Inhibitors and Cardiotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Current Oncology Reports"
DOI: 10.1007/s11912-021-01014-0
Abstract: Cancer and heart disease are the leading causes of mortality in the USA. Advances in cancer therapies, namely, the development and use of chemotherapeutic agents alone or in combination, are becoming increasingly prevalent. Many chemotherapeutic… read more here.
Keywords: microtubule; microtubule inhibitors; inhibitors cardiotoxicity; cardiotoxicity ... See more keywords
Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111949
Abstract: A combination therapeutic regimen via introducing tryptophan 2,3-dioxygenase inhibitors into microtubule inhibitors was performed and evaluated for their antitumor activity. Thereinto, HT2, composed of combretastatin A-4 (CA-4) and tryptophan-2,3-dioxygenase (TDO) inhibitor by a linker, displayed… read more here.
Keywords: microtubule inhibitors; tubulin polymerization; tryptophan dioxygenase; cancer ... See more keywords
Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02854
Abstract: Natural microtubule inhibitors, such as paclitaxel and ixabepilone, are key sources of novel medications, which have a considerable influence on anti-tumor chemotherapy. Natural product chemists have been encouraged to create novel methodologies for screening the… read more here.
Keywords: microtubule inhibitors; natural products; learning promotes; deep learning ... See more keywords
A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0455
Abstract: Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug resistance (MDR) in cancer is a major challenge for microtubule inhibitors in their clinical implementation. From a high-throughput drug… read more here.
Keywords: microtubule; microtubule inhibitors; inhibitor; multidrug resistance ... See more keywords
Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20120752
Abstract: Phenylahistin is a naturally occurring marine product with a diketopiperazine structure that can bind to the colchicine site of microtubulin as a possible anticancer agent. To develop more potent microtubule inhibitors, novel phenylahistin derivatives were… read more here.
Keywords: microtubule inhibitors; phenylahistin derivatives; novel phenylahistin; potent microtubule ... See more keywords