Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport
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DOI: 10.1038/s41380-022-01538-2
Abstract: The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer’s disease (AD). The exact molecular mechanisms underlying tau toxicity are unclear, but aging is irrefutably the biggest risk factor. This raises the… read more here.
Keywords: transport; axonal transport; interaction; microtubule interaction ... See more keywords