A Brownian Ratchet Model Explains the Biased Sidestepping of Single-Headed Kinesin-3 KIF1A.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.05.011
Abstract: The kinesin-3 motor KIF1A is involved in long-ranged axonal transport in neurons. To ensure vesicular delivery, motors need to navigate the microtubule lattice and overcome possible roadblocks along the way. The single-headed form of KIF1A… read more here.
Keywords: kif1a; single headed; microtubule lattice; motor ... See more keywords
CLASP2 facilitates dynamic actin filament organization along the microtubule lattice
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-05-0149
Abstract: Coordination between the microtubule and actin networks is essential for cell motility, neuronal growth cone guidance, and wound healing. Members of the CLASP (Cytoplasmic Linker-Associated Protein) family of proteins have been implicated in the cytoskeletal… read more here.
Keywords: microtubule lattice; actin; clasp2; microtubule ... See more keywords
Causes, costs and consequences of kinesin motors communicating through the microtubule lattice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260735
Abstract: ABSTRACT Microtubules are critical for a variety of important functions in eukaryotic cells. During intracellular trafficking, molecular motor proteins of the kinesin superfamily drive the transport of cellular cargoes by stepping processively along the microtubule… read more here.
Keywords: microtubule lattice; kinesin motors; microtubule; kinesin ... See more keywords