Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.11.021
Abstract: A series of imidazo[2,1-b][1,3,4]thiadiazole linked indolinone conjugates were synthesized and investigated for antiproliferative activity in different human cancer cell lines by changing various substitutions at indolinone and phenyl ring systems. Among them conjugates 7, 14… read more here.
Keywords: imidazo thiadiazole; microtubule network; apoptosis; linked indolinone ... See more keywords
Preservation of the microtubule network to beat atrial fibrillation: role of SR-mitochondrial contacts
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.0332
Abstract: Atrial fibrillation (AF), the most common tachyarrhythmia, is a progressive disease characterized by electrophathology, which is defined as the structural remodeling of atrial cardiomyocytes that underlies electrophysiological remodeling and contractile dysfunction and consequently AF progression.… read more here.
Keywords: microtubule; dysfunction; preservation microtubule; microtubule network ... See more keywords
Local changes in microtubule network mobility instruct neuronal polarization and axon specification
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DOI: 10.1126/sciadv.abo2343
Abstract: The polarization of neurons into axons and dendrites depends on extracellular cues, intracellular signaling, cytoskeletal rearrangements, and polarized transport, but the interplay between these processes during polarization remains unresolved. Here, we show that axon specification… read more here.
Keywords: axon specification; microtubule network; mobility; polarization ... See more keywords
Morphological Evidence for Novel Roles of Microtubules in Macrophage Phagocytosis
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DOI: 10.3390/ijms24021373
Abstract: Although the phagocytic activity of macrophages has long been studied, the involvement of microtubules in the process is not well understood. In this study, we improved the fixation protocol and revealed a dynamically rearranging microtubule… read more here.
Keywords: network; microtubule network; morphological evidence; evidence novel ... See more keywords