Kinesin-14 motors participate in a force balance at microtubule plus-ends to regulate dynamic instability
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108046119
Abstract: Significance Kinesin-14 motors represent an essential class of molecular motors that bind to microtubules and then walk toward the microtubule minus-end. However, whether these motors can interact with growing plus-ends of microtubules to impact the… read more here.
Keywords: kinesin motors; plus ends; microtubule plus; microtubule ... See more keywords
CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state–sensitive manner
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.abq5404
Abstract: CLASPs (cytoplasmic linker-associated proteins) are ubiquitous stabilizers of microtubule dynamics, but their molecular targets at the microtubule plus-end are not understood. Using DNA origami–based reconstructions, we show that clusters of human CLASP2 form a load-bearing… read more here.
Keywords: gtp tubulins; non gtp; gtp; microtubule plus ... See more keywords
Reconstitution of kinetochore motility and microtubule dynamics reveals a role for a kinesin-8 in establishing end-on attachments
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78450
Abstract: During mitosis, individual microtubules make attachments to chromosomes via a specialized protein complex called the kinetochore to faithfully segregate the chromosomes to daughter cells. Translocation of kinetochores on the lateral surface of the microtubule has… read more here.
Keywords: microscopy; reconstitution kinetochore; microtubule plus; microtubule ... See more keywords