Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01051-0
Abstract: The establishment of polarity is an essential process in early neuronal development. Cdc42, a GTPase of the Rho family, is a key regulator of cytoskeletal dynamics and neuronal polarity. However, the mechanisms underlying the action… read more here.
Keywords: axonogenesis; cdc42; hippocampal neurons; microtubule stabilization ... See more keywords
Articular fibrocartilage-targeted therapy by microtubule stabilization
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn8420
Abstract: The fibrocartilage presented on the joint surface was caused by cartilage injury or degeneration. There is still a lack of effective strategies for fibrocartilage. Here, we hypothesized that the fibrocartilage could be viewed as a… read more here.
Keywords: fibrocartilage; cartilage; articular fibrocartilage; microtubule stabilization ... See more keywords
Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1102318
Abstract: Intervertebral disc degeneration (IDD) is the cardinal pathological mechanism that underlies low back pain. Mechanical stress of the intervertebral disc may result in a change in nucleus pulposus cells state, matrix degradation, and degeneration of… read more here.
Keywords: pulposus; type collagen; stabilization promotes; microtubule stabilization ... See more keywords
Ancient Origins of Cytoskeletal Crosstalk: Spectraplakin-like Proteins Precede the Emergence of Cortical Microtubule Stabilization Complexes as Crosslinkers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105594
Abstract: Adhesion between cells and the extracellular matrix (ECM) is one of the prerequisites for multicellularity, motility, and tissue specialization. Focal adhesions (FAs) are defined as protein complexes that mediate signals from the ECM to major… read more here.
Keywords: cortical microtubule; cytoskeletal crosstalk; stabilization complexes; microtubule stabilization ... See more keywords