Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.8b00641
Abstract: Four new compounds (2-5) structurally related to the microtubule-stabilizing agent (-)-zampanolide (1) have been isolated from the Tongan marine sponge Cacospongia mycofijiensis. Three of these new structures, zampanolides B-D (2-4), exhibit nanomolar cytotoxicity toward the… read more here.
Keywords: microtubule stabilizing; sponge; sponge cacospongia; marine sponge ... See more keywords
Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders
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DOI: 10.3390/ijms18081627
Abstract: Neurodevelopmental disorders (NDDs) are characterized by neuroanatomical abnormalities indicative of corticogenesis disturbances. At the basis of NDDs cortical abnormalities, the principal developmental processes involved are cellular proliferation, migration and differentiation. NDDs are also considered “synaptic… read more here.
Keywords: microtubule; microtubule stabilizing; role microtubule; stabilizing agents ... See more keywords