Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3786
Abstract: Graphene‐based nanomaterials hold the potential to be used in a wide variety of applications, including biomedical devices. Pristine graphene (PG) is an un‐functionalized, defect‐free type of graphene that could be used as a material for… read more here.
Keywords: brain microvascular; pristine graphene; microvascular endothelial; endothelial cells ... See more keywords
Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4366
Abstract: Indoxyl sulphate (IS) is a uremic toxin accumulating in the plasma of chronic kidney disease (CKD) patients. IS accumulation induces side effects in the kidneys, bones and cardiovascular system. Most studies assessed IS effects on… read more here.
Keywords: human microvascular; uremic toxin; indoxyl sulphate; microvascular endothelial ... See more keywords
Piperine Decreases Binding of Drugs to Human Plasma and Increases Uptake by Brain Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5929
Abstract: We previously reported that piperine, an active alkaloidal principal of black and long peppers, enhances drug bioavailability by inhibiting drug metabolism. Another mechanism influencing drug availability/uptake is its free fraction. Since piperine is highly lipophilic,… read more here.
Keywords: human plasma; brain microvascular; drug; piperine ... See more keywords
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0640-7_10
Abstract: Cerebral cavernous malformations (CCMs) is a disorder of endothelial cells predominantly localized in the brain. Although a complete inactivation of each CCM protein has been found in the affected endothelium of diseased patients and a… read more here.
Keywords: generation ccm; ccm phenotype; ccm; endothelial model ... See more keywords
Isolation and Culture of Brain Microvascular Endothelial Cells for In Vitro Blood-Brain Barrier Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_23
Abstract: The blood-brain barrier (BBB) is essential to maintain the proper microenvironment for brain function. Although formed by different cell types, the endothelial cells (ECs) of the brain microvessels provide the BBB with its selective permeability.… read more here.
Keywords: blood brain; brain microvascular; microvascular endothelial; endothelial cells ... See more keywords
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance.
Sign Up to like & getrecommendations! Published in 2022 at "Angiogenesis"
DOI: 10.1007/s10456-022-09835-8
Abstract: Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes, and can accelerate diabetes-related microvascular and macrovascular complications by promoting vasoconstrictive, pro-inflammatory and pro-thrombotic responses. Perturbed mitochondrial function induces oxidative stress, disrupts… read more here.
Keywords: coronary microvascular; mitochondrial quality; microvascular endothelial; endothelial dysfunction ... See more keywords
Pure ultra-fine carbon particles do not exert pro-coagulation and inflammatory effects on microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-3783-3
Abstract: Pro-thrombotic and inflammatory changes play an important role in cardiovascular morbidity and mortality, resulting from short-term exposure to fine particulate air-pollution. Part of those effects has been attributed to the ultra-fine particles (UFPs) that pass… read more here.
Keywords: carbon; particles exert; inflammatory; microvascular endothelial ... See more keywords
Regulation of Human Brain Microvascular Endothelial Cell Adhesion and Barrier Functions by Memantine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0917-x
Abstract: Vascular risk factors have been linked to cognitive decline and dementia in the elderly. Microvascular inflammation, especially of the endothelium, may contribute to the progression of neurodegenerative events in Alzheimer’s disease (AD). Memantine, an uncompetitive… read more here.
Keywords: cell adhesion; brain microvascular; microvascular endothelial; human brain ... See more keywords
Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01326-8
Abstract: The destruction of the blood-brain barrier (BBB) contributes to a spectrum of neurological diseases such as stroke, and the hyperpermeability of endothelial cells is one of the characters of stroke, which is possibly exacerbated after… read more here.
Keywords: hbmec monolayers; hyperpermeability; internalization; glucose deprivation ... See more keywords
The Protective Effects of Ramelteon Against Isoflurane-Induced Insults and Inflammatory Response in Brain Microvascular Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity research"
DOI: 10.1007/s12640-020-00309-7
Abstract: Anesthetic-induced cognitive impairment has been observed clinically. The mechanism underlying anesthetic-induced cognitive impairment is closely associated with neuronal apoptosis and neuroinflammation. Ramelteon is a potent and highly selective melatonin receptor agonist that has been used… read more here.
Keywords: brain microvascular; isoflurane induced; microvascular endothelial; endothelial cells ... See more keywords
Statins protect diabetic myocardial microvascular endothelial cells from injury
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-018-0646-x
Abstract: To study the protective effect and mechanism of statins on myocardial microvascular endothelial cells injury in diabetic rats. The rats were administrated with atorvastatin (10 mg/kg/day), rosuvastatin (5 mg/kg/day), or placebo for 1 week. The expression of small… read more here.
Keywords: statins protect; myocardial microvascular; microvascular endothelial; endothelial cells ... See more keywords