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   Articles with "micu1" as a keyword



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MICU1 Confers Protection from MCU-Dependent Manganese Toxicity.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.10.037

Abstract: The mitochondrial calcium uniporter is a highly selective ion channel composed of species- and tissue-specific subunits. However, the functional role of each component still remains unclear. Here, we establish a synthetic biology approach to dissect… read more here.

Keywords: micu1 confers; confers protection; protection mcu; mcu dependent ... See more keywords
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Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2217665120

Abstract: The mitochondrial calcium uniporter is a Ca2+ channel that imports cytoplasmic Ca2+ into the mitochondrial matrix to regulate cell bioenergetics, intracellular Ca2+ signaling, and apoptosis. The uniporter contains the pore-forming MCU subunit, an auxiliary EMRE… read more here.

Keywords: calcium uniporter; micu1; micu1 occlusion; mitochondrial calcium ... See more keywords
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Abstract 270: Micu1 Regulates Mitochondrial Structural Integrity and Cristae Function Independent of Mcu Calcium Uptake

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recommendations! Published in 2020 at "Circulation Research"

DOI: 10.1161/res.127.suppl_1.270

Abstract: MICU1 is a Ca 2+ -sensor regulating the mitochondrial Ca 2+ uniporter channel (mtCU) and mitochondrial Ca 2+ uptake. MICU1 contains two Ca 2+ - binding EF-hand domains and directly interacts with the mtCU pore-forming… read more here.

Keywords: cristae; micos; mcu; regulates mitochondrial ... See more keywords
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The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis

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recommendations! Published in 2021 at "EMBO reports"

DOI: 10.15252/embr.202051532

Abstract: Ferroptosis has recently attracted much interest because of its relevance to human diseases such as cancer and ischemia‐reperfusion injury. We have reported that prolonged severe cold stress induces lipid peroxidation‐dependent ferroptosis, but the upstream mechanism… read more here.

Keywords: mitochondrial ca2; ferroptosis; stress induced; micu1 ... See more keywords
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Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23158629

Abstract: Background: Oocyte vitrification has been widely used in the treatment of infertility and fertility preservation. However, vitrification-induced mitochondrial damage adversely affects oocyte development. Several studies have reported that mitochondrial calcium uptake protein 1 (MICU1) regulates… read more here.

Keywords: calcium; vitrification; micu1; calcium uptake ... See more keywords