Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex.
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DOI: 10.1073/pnas.2217665120
Abstract: The mitochondrial calcium uniporter is a Ca2+ channel that imports cytoplasmic Ca2+ into the mitochondrial matrix to regulate cell bioenergetics, intracellular Ca2+ signaling, and apoptosis. The uniporter contains the pore-forming MCU subunit, an auxiliary EMRE… read more here.
Keywords: calcium uniporter; micu1; micu1 occlusion; mitochondrial calcium ... See more keywords