The effect of mid-life insulin resistance and type 2 diabetes on older-age cognitive state: the explanatory role of early-life advantage
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4949-3
Abstract: Aims/hypothesisType 2 diabetes, hyperglycaemia and insulin resistance are associated with cognitive impairment and dementia, but causal inference studies using Mendelian randomisation do not confirm this. We hypothesised that early-life cognition and social/educational advantage may confound… read more here.
Keywords: cognitive state; age; type diabetes; mid life ... See more keywords
Childhood Maltreatment and Mid-Life Adult Sexuality: A 10-Year Longitudinal Study.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of sexual behavior"
DOI: 10.1007/s10508-021-02030-8
Abstract: One important long-term outcome of childhood maltreatment is thought to be impairments in intimate relationships. However, the specific nature of these impairments is not well understood. To address this gap, we examined the long-term relation… read more here.
Keywords: adult sexuality; sex; mid life; childhood maltreatment ... See more keywords
Obesity in early adulthood and physical functioning in mid-life: Investigating the mediating role of c-reactive protein
Sign Up to like & getrecommendations! Published in 2022 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2022.03.008
Abstract: INTRODUCTION Obesity in adulthood is associated with reduced physical functioning (PF) at older ages. However, mechanisms underpinning this association are not well understood. We investigated whether and the extent to which C-reactive protein (CRP) mediates… read more here.
Keywords: obesity; physical functioning; effect; mid life ... See more keywords
Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.06.012
Abstract: This study tested the hypothesis that mid-life intellectual, physical, and social activities contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic resonance imaging) aged 66-88 years from the Cambridge Centre for Ageing… read more here.
Keywords: contribute cognitive; life activities; cognitive reserve; late life ... See more keywords
How Well Do Measurement Scales Reflect the Actual Experience of Sexuality in Mid-Life and Beyond?
Sign Up to like & getrecommendations! Published in 2019 at "Sexual medicine reviews"
DOI: 10.1016/j.sxmr.2018.04.004
Abstract: BACKGROUND There is limited evidence that current sexuality measures accurately reflect the experience of sexuality among older people. AIM This review investigates whether sexuality scales that examine aspects of sexuality for heterosexual men and women… read more here.
Keywords: experience sexuality; measurement scales; life beyond; mid life ... See more keywords
Does an inflammatory diet affect mental well-being in late childhood and mid-life? A cross-sectional study
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Nutrition"
DOI: 10.1017/s0007114521001616
Abstract: Abstract Inflammatory diets are increasingly recognised as a modifiable determinant of mental illness. However, there is a dearth of studies in early life and across the full mental well-being spectrum (mental illness to positive well-being)… read more here.
Keywords: inflammatory diet; mid life; mental well; childhood ... See more keywords
The effects of omega-3 fatty acids on neuropsychological functioning and brain morphology in mid-life adults: a randomized clinical trial
Sign Up to like & getrecommendations! Published in 2019 at "Psychological Medicine"
DOI: 10.1017/s0033291719002617
Abstract: Abstract Background The diet of most adults is low in fish and, therefore, provides limited quantities of the long-chain, omega-3 fatty acids (LCn-3FAs), eicosapentaenoic and docosahexaenoic acids (EPA, DHA). Since these compounds serve important roles… read more here.
Keywords: life adults; supplementation; brain morphology; mid life ... See more keywords
Reducing mid-life cardiovascular disease by improving reproductive health
Sign Up to like & getrecommendations! Published in 2018 at "Climacteric"
DOI: 10.1080/13697137.2018.1537355
Abstract: Worldwide more than 8 million women die as a consequence of cardiovascular disease (CVD), including heart disease and stroke. Aging and the inexorable decrease of ovarian estrogenic secretion are two relevant factors. It is well… read more here.
Keywords: risk; pregnancy; disease; mid life ... See more keywords
Mid-life social participation and physical performance at age 60-64: evidence from the 1946 British Birth Cohort Study.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of public health"
DOI: 10.1093/eurpub/ckz005
Abstract: Background Previous studies linking social activity and disability have been limited by focussing on self-reported physical performance in older adults (>65). We examined whether social participation in mid-life is associated with objective and subjective measures… read more here.
Keywords: participation; age; physical performance; social participation ... See more keywords
Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13808
Abstract: Telomere attrition is one of biological aging hallmarks and may be intervened to target multiple aging-related diseases, including Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). The objective of this study was to assess associations… read more here.
Keywords: 435 046; telomere length; mid life; leukocyte telomere ... See more keywords
Influence of childhood socioeconomic position and ability on mid-life cognitive function: evidence from three British birth cohorts
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Epidemiology and Community Health"
DOI: 10.1136/jech-2020-215637
Abstract: Background Childhood socioeconomic position (SEP) is robustly associated with cognitive function later in life. However, it is unclear whether this reflects a direct relationship, or an indirect association via modifiable factors such as educational attainment… read more here.
Keywords: childhood; function; life cognitive; mid life ... See more keywords