Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children
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DOI: 10.1001/jamanetworkopen.2023.6990
Abstract: This cohort study assesses the effectiveness of midazolam treatment in terminating pediatric seizures in the prehospital setting. read more here.
Keywords: midazolam prehospital; line therapy; midazolam; first line ... See more keywords
Evaluation of the Effects of Repeat‐Dose Dabrafenib on the Single‐Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate)
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.937
Abstract: Dabrafenib is an oral BRAF kinase inhibitor approved for the treatment of various BRAF V600 mutation–positive solid tumors. In vitro observations suggesting cytochrome P450 (CYP) 3A induction and organic anion transporting polypeptide (OATP) inhibition prompted… read more here.
Keywords: oatp1b1 1b3; 1b3 substrate; midazolam; time ... See more keywords
Impact of Inflammation on Midazolam Metabolism in Severe COVID‐19 Patients
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DOI: 10.1002/cpt.2698
Abstract: Midazolam is a benzodiazepine frequently used for sedation in patients hospitalized in the intensive care unit (ICU) for coronavirus disease 2019 (COVID‐19). This drug is primarily metabolized by cytochrome P450 3A (CYP3A) isoenzymes. Several studies… read more here.
Keywords: cyp3a; inflammation; metabolism; inflammation midazolam ... See more keywords
Combination of antiseizure medications phenobarbital, ketamine and midazolam reduces soman-induced epileptogenesis and brain pathology in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia open"
DOI: 10.1002/epi4.12552
Abstract: OBJECTIVE Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that may contribute to pharmacoresistance… read more here.
Keywords: ketamine; midazolam; pathology; soman induced ... See more keywords
The effects of lapatinib on CYP3A metabolism of midazolam in patients with advanced cancer
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DOI: 10.1007/s00280-017-3470-y
Abstract: PurposeThe potential inhibition of CYP3A4 by lapatinib was studied using midazolam as a probe substrate in patients with cancer.MethodsThis was a partially randomized, 4-period, 4-sequence, 4-treatment, cross-over study in 24 patients with advanced cancer. Single… read more here.
Keywords: patients advanced; midazolam; effects lapatinib; cancer ... See more keywords
Comparison of single minimum dose administration of dexmedetomidine and midazolam for prevention of emergence delirium in children: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Anesthesia"
DOI: 10.1007/s00540-019-02705-6
Abstract: Purpose Emergence delirium (ED) is common in children after sevoflurane anesthesia and should be prevented for patient safety. A prospective, double-blind, randomized, controlled study was performed to compare the efficacy of minimal dosage of midazolam… read more here.
Keywords: dexmedetomidine; emergence delirium; group; midazolam ... See more keywords
Clinically relevant concentration of propofol and benzodiazepines did not affect in vitro angiogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Anesthesia"
DOI: 10.1007/s00540-021-02993-x
Abstract: Angiogenesis, one of regenerative medicine, is essential in the process of wound healing. The detailed effects of intravenous anesthetics and sedatives used during perioperative period have not yet been clarified. We investigated the effects of… read more here.
Keywords: propofol; angiogenesis; midazolam; vitro angiogenesis ... See more keywords
Efficacy of novel sedation using the combination of dexmedetomidine and midazolam during endoscopic submucosal dissection for esophageal squamous cell carcinoma
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DOI: 10.1007/s10388-019-00666-z
Abstract: BackgroundEndoscopic submucosal dissection (ESD) is the preferred treatment for esophageal squamous cell carcinoma (ESCC). However, ESD can be difficult when patients move due to insufficient sedation. We conducted a prospective confirmatory single arm study to… read more here.
Keywords: combination; submucosal dissection; midazolam; sedation ... See more keywords
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects
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DOI: 10.1007/s12325-017-0601-0
Abstract: IntroductionObeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug–drug interaction effect of OCA on metabolic CYP450 enzymes and… read more here.
Keywords: dextromethorphan; digoxin; rosuvastatin; warfarin ... See more keywords
Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway
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DOI: 10.1007/s13577-017-0184-8
Abstract: Midazolam is a sedative used by patients with mechanical ventilation. However, the potential clinical value is not fully explored. In this report, we made use of a neuroblastoma-spinal cord hybrid motor neuron-like cell line NSC34,… read more here.
Keywords: oxidative stress; jnk erk; midazolam; jnk ... See more keywords
Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2
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DOI: 10.1016/j.brainresbull.2020.04.016
Abstract: Excitotoxicity is one of the main mechanisms related to hypoxia/reoxygenation (H/R) injury. Excitatory amino acid transporter (EAAT)2 mainly distributes on astrocytes and plays an important role on glutamate reuptake and glutamate homeostasis. Midazolam has a… read more here.
Keywords: neuroprotective effect; hypoxia reoxygenation; midazolam; brain ... See more keywords