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   Articles with "midbrain" as a keyword



Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24167

Abstract: The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids. Human iPSC-derived midbrain organoids consist of differentiated and functional neurons,… read more here.

Keywords: ipsc derived; integration human; microglia midbrain; microglia integration ... See more keywords

Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24295

Abstract: Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro‐inflammatory stimulus was… read more here.

Keywords: disease; model parkinson; parkinson disease; midbrain ... See more keywords

Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration

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recommendations! Published in 2025 at "Psychopharmacology"

DOI: 10.1007/s00213-025-06747-5

Abstract: Despite decades of research and medical development, relapse to drug seeking continues to be a significant challenge in the treatment of substance use disorders. GABAB receptor (GABAB-R) agonists have been shown preclinically to inhibit relapse… read more here.

Keywords: fentanyl; dopamine neurons; midbrain dopamine; prolonged abstinence ... See more keywords

Neuroimaging of septo-optic dysplasia-plus with midbrain hypoplasia and ophthalmoplegia

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recommendations! Published in 2020 at "eNeurologicalSci"

DOI: 10.1016/j.ensci.2020.100235

Abstract: Septo-optic dysplasia is a rare brain malformation that can be associated with anomalous cortical development, such as schizencephaly, which is referred to as septo-optic dysplasia plus. This report describes septo-optic dysplasia-plus associated with unilateral atrophy… read more here.

Keywords: optic dysplasia; midbrain; neuroimaging septo; dysplasia plus ... See more keywords

Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons

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recommendations! Published in 2018 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2018.01.009

Abstract: HighlightsHCAs produce selective loss of dopamine neurons in primary midbrain cultures.The threshold dose for selective neurotoxicity is HCA‐dependent.HCAs generally elicit selective dopaminergic neurite retraction.MeIQ and harmane increases oxidative damage in dopamine neurons. ABSTRACT Heterocyclic amines… read more here.

Keywords: selective dopaminergic; midbrain; dopaminergic neurotoxicity; neurotoxicity ... See more keywords
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Ring of Power: A Band of Peptidergic Midbrain Neurons that Binds Motivation

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recommendations! Published in 2019 at "Neuron"

DOI: 10.1016/j.neuron.2019.07.022

Abstract: A recent Cell paper identifies a novel population of neurons within the ventral tegmental area producing the endogenous opioid nociceptin that regulates dopamine neuron firing and acts uniquely to gate motivation in reward seeking. These… read more here.

Keywords: ring power; power band; band peptidergic; midbrain ... See more keywords
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Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons

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recommendations! Published in 2019 at "Neuron"

DOI: 10.1016/j.neuron.2019.08.026

Abstract: The periaqueductal gray (PAG) in the midbrain is known to coordinate behavioral and autonomic responses to threat and injury through its descending projections to the brainstem. Here, we show that neurotensin (NTS)-expressing glutamatergic neurons in… read more here.

Keywords: rem sleep; non rem; nrem sleep; midbrain ... See more keywords

Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice.

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recommendations! Published in 2020 at "Neurotoxicology and teratology"

DOI: 10.1016/j.ntt.2020.106887

Abstract: Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders and manifests inattention, hyperactivity, and impulsivity symptoms in childhood that can last throughout life. Genetic and environmental studies implicate the dopamine system in… read more here.

Keywords: deltamethrin corticosterone; midbrain; hypermethylation; exposure ... See more keywords

Deciphering midbrain mechanisms underlying prepulse inhibition of startle

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recommendations! Published in 2020 at "Progress in Neurobiology"

DOI: 10.1016/j.pneurobio.2019.101734

Abstract: Prepulse inhibition (PPI) is an operational measure of sensorimotor gating. Deficits of PPI are a hallmark of schizophrenia and associated with several other psychiatric illnesses such as e.g. autism spectrum disorder, yet the mechanisms underlying… read more here.

Keywords: ppi; inhibition; prepulse inhibition; midbrain ... See more keywords
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Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease.

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recommendations! Published in 2020 at "Stem cell research"

DOI: 10.1016/j.scr.2020.101870

Abstract: The study of human midbrain development and midbrain related diseases, like Parkinson's disease (PD), is limited by deficiencies in the currently available and validated laboratory models. Three dimensional midbrain organoids represent an innovative strategy to… read more here.

Keywords: midbrain organoids; midbrain; human midbrain; parkinson disease ... See more keywords

Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-24524-8

Abstract: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and autonomic… read more here.

Keywords: aav2; amino acid; delivery; midbrain ... See more keywords