Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24167
Abstract: The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids. Human iPSC-derived midbrain organoids consist of differentiated and functional neurons,… read more here.
Keywords: ipsc derived; integration human; microglia midbrain; microglia integration ... See more keywords
Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24295
Abstract: Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro‐inflammatory stimulus was… read more here.
Keywords: disease; model parkinson; parkinson disease; midbrain ... See more keywords
Neuroimaging of septo-optic dysplasia-plus with midbrain hypoplasia and ophthalmoplegia
Sign Up to like & getrecommendations! Published in 2020 at "eNeurologicalSci"
DOI: 10.1016/j.ensci.2020.100235
Abstract: Septo-optic dysplasia is a rare brain malformation that can be associated with anomalous cortical development, such as schizencephaly, which is referred to as septo-optic dysplasia plus. This report describes septo-optic dysplasia-plus associated with unilateral atrophy… read more here.
Keywords: optic dysplasia; midbrain; neuroimaging septo; dysplasia plus ... See more keywords
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.01.009
Abstract: HighlightsHCAs produce selective loss of dopamine neurons in primary midbrain cultures.The threshold dose for selective neurotoxicity is HCA‐dependent.HCAs generally elicit selective dopaminergic neurite retraction.MeIQ and harmane increases oxidative damage in dopamine neurons. ABSTRACT Heterocyclic amines… read more here.
Keywords: selective dopaminergic; midbrain; dopaminergic neurotoxicity; neurotoxicity ... See more keywords
Ring of Power: A Band of Peptidergic Midbrain Neurons that Binds Motivation
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.07.022
Abstract: A recent Cell paper identifies a novel population of neurons within the ventral tegmental area producing the endogenous opioid nociceptin that regulates dopamine neuron firing and acts uniquely to gate motivation in reward seeking. These… read more here.
Keywords: ring power; power band; band peptidergic; midbrain ... See more keywords
Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.08.026
Abstract: The periaqueductal gray (PAG) in the midbrain is known to coordinate behavioral and autonomic responses to threat and injury through its descending projections to the brainstem. Here, we show that neurotensin (NTS)-expressing glutamatergic neurons in… read more here.
Keywords: rem sleep; non rem; nrem sleep; midbrain ... See more keywords
Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2020.106887
Abstract: Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders and manifests inattention, hyperactivity, and impulsivity symptoms in childhood that can last throughout life. Genetic and environmental studies implicate the dopamine system in… read more here.
Keywords: deltamethrin corticosterone; midbrain; hypermethylation; exposure ... See more keywords
Deciphering midbrain mechanisms underlying prepulse inhibition of startle
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2019.101734
Abstract: Prepulse inhibition (PPI) is an operational measure of sensorimotor gating. Deficits of PPI are a hallmark of schizophrenia and associated with several other psychiatric illnesses such as e.g. autism spectrum disorder, yet the mechanisms underlying… read more here.
Keywords: ppi; inhibition; prepulse inhibition; midbrain ... See more keywords
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101870
Abstract: The study of human midbrain development and midbrain related diseases, like Parkinson's disease (PD), is limited by deficiencies in the currently available and validated laboratory models. Three dimensional midbrain organoids represent an innovative strategy to… read more here.
Keywords: midbrain organoids; midbrain; human midbrain; parkinson disease ... See more keywords
Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24524-8
Abstract: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and autonomic… read more here.
Keywords: aav2; amino acid; delivery; midbrain ... See more keywords
Transsylvian, Carotid-Oculomotor Triangle Approach for Resection of a Rapidly Enlarging Midbrain-Pontine Cavernous Malformation: 3-Dimensional Operative Video.
Sign Up to like & getrecommendations! Published in 2019 at "Operative neurosurgery"
DOI: 10.1093/ons/opy390
Abstract: Cavernous malformations (CM) of the anterior midbrain are best reached through an orbitozygomatic (OZ) approach with removal of the orbital rim and wide Sylvian fissure dissection. Our surgical video demonstrates this approach to resect a… read more here.
Keywords: video; oculomotor triangle; midbrain; approach ... See more keywords