Salusin-β mediate neuroprotective effects for Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.059
Abstract: Neuropeptides, small peptides found in many mammalian brain, play key roles in communicating with each other to modulate neuronal activity. Here, we reported that endogenous neuropeptide salusin-β has neuroprotective effects on the midbrain dopamine neurons… read more here.
Keywords: midbrain dopamine; salusin; neuroprotective effects; parkinson disease ... See more keywords
Oxytocin Mobilizes Midbrain Dopamine toward Sociality
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.07.002
Abstract: Oxytocin and dopamine possess significant overlap in the modulation of life-essential behaviors. Here, Xiao et al. (2017) show that the activity of dopamine neurons of the ventral tegmental area and the substantia nigra is finely tuned… read more here.
Keywords: midbrain dopamine; dopamine toward; oxytocin; mobilizes midbrain ... See more keywords
Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.07.005
Abstract: Early gestation is a neurodevelopmental period that is especially vulnerable to environmental insult and one in which neurogenesis features prominently. Prenatal perturbation during early gestation has been linked to neuropsychiatric illnesses such as autism and… read more here.
Keywords: adult; midbrain dopamine; neuron number; reduced midbrain ... See more keywords
Seq-ing Markers of Midbrain Dopamine Neurons.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.014
Abstract: Transplantation of human pluripotent stem cell-derived dopaminergic neurons is a promising approach to treating Parkinson's disease. In this issue of Cell Stem Cell, Kee et al. (2017) and Kirkeby et al. (2017) identify specific markers of midbrain… read more here.
Keywords: midbrain dopamine; markers midbrain; ing markers; stem cell ... See more keywords
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell stem cell"
DOI: 10.1016/j.stem.2022.01.013
Abstract: Midbrain dopamine (mDA) neurons can be replaced in patients with Parkinson's disease (PD) in order to provide long-term improvement in motor functions. The limited capacity for long-distance axonal growth in the adult brain means that… read more here.
Keywords: dopamine; human pluripotent; pluripotent stem; cell ... See more keywords
Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00715
Abstract: Targeting neurons with light-driven opsins is widely used to investigate cell-specific responses. We transfected midbrain dopamine neurons with the excitatory opsin Chrimson. Extracellular basal and stimulated neurotransmitter levels in the dorsal striatum were measured by… read more here.
Keywords: serotonin; dopamine; midbrain dopamine; dopamine neurons ... See more keywords
When does midbrain dopamine activity exert its effects on behavior?
Sign Up to like & getrecommendations! Published in 2020 at "Nature Neuroscience"
DOI: 10.1038/s41593-019-0577-y
Abstract: Rewards direct behavioral adaptation through midbrain dopamine signaling, though the timing of those effects is often ambiguous. Lee and colleagues find that different subpopulations of dopamine neurons obey similar constraints, indirectly regulating reward-related behavior through… read more here.
Keywords: midbrain dopamine; dopamine activity; activity exert; exert effects ... See more keywords
Midbrain dopamine neurons arbiter OCD-like behavior
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207545119
Abstract: Significance Repetitive stereotyped behavior is a common symptom in various psychiatric disorders, such as obsessive–compulsive disorder (OCD). The midbrain dopaminergic system has been implicated in this phenotype, but the precise location and circuit mechanism whereby… read more here.
Keywords: ocd like; behavior; neurons arbiter; midbrain dopamine ... See more keywords
The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.851067
Abstract: Deep-brain stimulation of the medial forebrain bundle (MFB) can provide effective, enduring relief of treatment-resistant depression. Panksepp provided an explanatory framework: the MFB constitutes the core of the neural circuitry subserving the anticipation and pursuit… read more here.
Keywords: depression; brain; midbrain dopamine; self stimulation ... See more keywords
Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2020.00613
Abstract: Dysregulation of the dopamine system is central to many models of the pathophysiology of psychosis in schizophrenia. However, emerging evidence suggests that this dysregulation is driven by the disruption of upstream circuits that provide afferent… read more here.
Keywords: schizophrenia; midbrain dopamine; dysregulation; dopamine ... See more keywords
In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.48408
Abstract: Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA neurons have been… read more here.
Keywords: midbrain dopamine; dopamine neurons; functional diversity; diversity midbrain ... See more keywords