α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
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DOI: 10.1002/advs.202409040
Abstract: Understanding the progression of α‐synuclein pathology in neurodegenerative diseases such as Parkinson's disease (PD) is a longstanding challenge. Here, a novel midbrain–hindbrain‐assembloid model that recapitulates the spread of α‐synuclein pathology observed in PD patients, akin… read more here.
Keywords: pathology; model; synuclein pathology; midbrain hindbrain ... See more keywords
Basal constriction during midbrain–hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase
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DOI: 10.1242/bio.034520
Abstract: ABSTRACT Basal constriction occurs at the zebrafish midbrain–hindbrain boundary constriction (MHBC) and is likely a widespread morphogenetic mechanism. 3D reconstruction demonstrates that MHBC cells are wedge-shaped, and initially constrict basally, with subsequent apical expansion. wnt5b… read more here.
Keywords: focal adhesion; constriction; midbrain hindbrain; hindbrain boundary ... See more keywords
Genome-wide 5-hydroxymethylcytosine (5hmC) reassigned in Pten-depleted mESCs along neural differentiation
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DOI: 10.3389/fcell.2022.956604
Abstract: DNA methylation and hydroxymethylation have been implicated in the regulatory dynamics of gene expression in normal development and differentiation. 5-Hydroxymethylcytosine (5hmC), created by the ten-eleven translocation (TET) protein-catalyzed oxidation of 5-methylcytosine (5mC), is abundant in… read more here.
Keywords: differentiation; genome wide; midbrain hindbrain; hydroxymethylcytosine 5hmc ... See more keywords