Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24167
Abstract: The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids. Human iPSC-derived midbrain organoids consist of differentiated and functional neurons,… read more here.
Keywords: ipsc derived; integration human; microglia midbrain; microglia integration ... See more keywords
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101870
Abstract: The study of human midbrain development and midbrain related diseases, like Parkinson's disease (PD), is limited by deficiencies in the currently available and validated laboratory models. Three dimensional midbrain organoids represent an innovative strategy to… read more here.
Keywords: midbrain organoids; midbrain; human midbrain; parkinson disease ... See more keywords
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.01.020
Abstract: Summary Recent advances in generating three-dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling and drug screening because organoids can recapitulate aspects of in vivo architecture and physiology. In this study,… read more here.
Keywords: midbrain organoids; sporadic parkinson; disease; parkinson disease ... See more keywords
Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00359
Abstract: The study of human 3D cell culture models not only bridges the gap between traditional 2D in vitro experiments and in vivo animal models, it also addresses processes that cannot be recapitulated by either of… read more here.
Keywords: midbrain organoids; midbrain; biology; parkinson disease ... See more keywords
Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.941984
Abstract: Background: Conventional animal models used in corresponding basic studies are distinct from humans in terms of the brain’s development trajectory, tissue cytoarchitecture and cell types, making it difficult to accurately evaluate the potential adverse effects… read more here.
Keywords: hipsc derived; sevoflurane; differentiation; exposure ... See more keywords
Generation and characterization of NGLY1 patient-derived midbrain organoids
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1039182
Abstract: NGLY1 deficiency is an ultra-rare, autosomal recessive genetic disease caused by mutations in the NGLY1 gene encoding N-glycanase one that removes N-linked glycan. Patients with pathogenic mutations in NGLY1 have complex clinical symptoms including global… read more here.
Keywords: derived midbrain; disease; patient; patient derived ... See more keywords
Patient-Derived Midbrain Organoids to Explore the Molecular Basis of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2020.01005
Abstract: Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex human tissues that recapitulate features of architecture, composition and function of in vivo organs. In the context of Parkinson's Disease (PD), human midbrain organoids… read more here.
Keywords: disease; midbrain organoids; derived midbrain; organoids explore ... See more keywords
Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.80271
Abstract: Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons (DA) at the substantia nigra pas compacta (SNpc). Cell therapy has been proposed as a potential treatment option… read more here.
Keywords: motor function; parkinson disease; motor; mouse model ... See more keywords
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52904
Abstract: Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS). However, current protocols yield either complex but highly heterogeneous aggregates (‘organoids’) or 3D structures with… read more here.
Keywords: human midbrain; fully automated; midbrain organoids; high throughput ... See more keywords