Impaired visceral pain-related functions of the midbrain periaqueductal gray in rats with colitis
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DOI: 10.1016/j.brainresbull.2022.02.002
Abstract: The midbrain periaqueductal gray (PAG) is a key structure involved in the supraspinal modulation of pain. Previous studies have reported the association of gut inflammation-triggered chronic abdominal pain with structural and neuronal alterations within the… read more here.
Keywords: visceral pain; midbrain periaqueductal; periaqueductal gray; pain ... See more keywords
Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway
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DOI: 10.1111/bph.14982
Abstract: The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that… read more here.
Keywords: midbrain periaqueductal; presynaptic disinhibition; periaqueductal grey; opioid presynaptic ... See more keywords