Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain
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DOI: 10.1002/pro.4126
Abstract: Hsp104, a yeast protein disaggregase, can be potentiated via numerous missense mutations at disparate locations throughout the coiled‐coil middle domain (MD). Potentiated Hsp104 variants can counter the toxicity and misfolding of TDP‐43, FUS, and α‐synuclein,… read more here.
Keywords: scanning mutagenesis; drivers hsp104; hsp104 potentiation; potentiation ... See more keywords
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foy042
Abstract: Hsp104 is a hexameric AAA + ATPase and protein disaggregase found in yeast, which can be potentiated via mutations in its middle domain (MD) to counter toxic phase separation by TDP-43, FUS and α-synuclein connected to devastating… read more here.
Keywords: potentiating hsp104; mutations middle; activity via; hsp104 activity ... See more keywords