Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody.
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DOI: 10.1021/acs.analchem.8b02398
Abstract: Pairing light and heavy chains in monoclonal antibodies (mAbs) using top-down (TD) or middle-down (MD) mass spectrometry (MS) may complement the sequence information on single chains provided by high-throughput genomic sequencing and bottom-up proteomics, favoring… read more here.
Keywords: chain; mass spectrometry; light heavy; mass ... See more keywords