Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-018-4882-y
Abstract: IntroductionNUT midline carcinoma is a rare tumour occurring in young adults which is frequently misdiagnosed as poorly differentiated squamous cell carcinoma or germ cell tumour. Though considered highly aggressive, there is limited information about the… read more here.
Keywords: midline carcinoma; carcinoma; analysis; nut midline ... See more keywords
Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma
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DOI: 10.1016/j.celrep.2017.08.082
Abstract: Summary Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline… read more here.
Keywords: nut midline; kinase; midline carcinoma; nmc cells ... See more keywords
Abstract 648: Digital PCR in genetic diagnosis of NUT midline carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-648
Abstract: Background; NUT midline carcinoma (NMC) is a rare, highly aggressive tumor with t(15;19) translocation involving NUT midline carcinoma family member 1 (NUTM1) gene. NMC is genetically defined and diagnosed by RNA sequencing or by immunohistochemistry… read more here.
Keywords: midline carcinoma; pcr; nut midline; digital pcr ... See more keywords
Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma
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DOI: 10.1186/s13023-020-01449-x
Abstract: Objective NUT midline carcinoma (NMC), a rare type of squamous cell carcinoma, is genetically characterised by NUT midline carcinoma family member 1 (NUTM1) gene rearrangement. NMC can arise from the lungs; however, there is no… read more here.
Keywords: pulmonary nmc; midline carcinoma; carcinoma; primary pulmonary ... See more keywords
Vimentin-positive and Alpha-fetoprotein-elevated Nuclear Protein of the Testis Midline Carcinoma: A Case Report and Review of the Literature.
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DOI: 10.2169/internalmedicine.7019-21
Abstract: Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare malignant tumor expressing NUT with BRD4/3 rearrangements and is sometimes misdiagnosed as germinoma, especially in alpha-fetoprotein (AFP)-elevated cases. A 28-year-old man had a… read more here.
Keywords: protein testis; midline carcinoma; nuclear protein; vimentin positive ... See more keywords
Sinonasal NUT midline carcinoma: A new histological entity
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DOI: 10.4103/ijpm.ijpm_373_19
Abstract: Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are… read more here.
Keywords: entity; nut midline; carcinoma; sinonasal nut ... See more keywords
Analysis of DNA methylation and microRNA expression in NUT (nuclear protein in testis) midline carcinoma of the sinonasal tract: a clinicopathological, immunohistochemical and molecular genetic study.
Sign Up to like & getrecommendations! Published in 2018 at "Neoplasma"
DOI: 10.4149/neo_2018_161122n581
Abstract: The aim of this study was a detailed clinicopathological investigation of sinonasal NUT midline carcinoma (NMC), including analysis of DNA methylation and microRNA (miRNA) expression. Three (5%) cases of NMC were detected among 56 sinonasal… read more here.
Keywords: analysis dna; methylation; midline carcinoma; expression ... See more keywords