A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24189
Abstract: Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are… read more here.
Keywords: diffuse midline; mouse; origin dependent; midline glioma ... See more keywords
Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma
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DOI: 10.1007/s00062-021-01120-3
Abstract: Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1… read more here.
Keywords: molecular subgroups; diffuse midline; k27m; midline glioma ... See more keywords
Diffuse midline glioma metastasis to the peritoneal cavity via ventriculo-peritoneal shunt: Case report and review of literature
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.06.043
Abstract: Extraneural dissemination of primary intracranial tumours to the peritoneal cavity via ventriculoperitoneal shunts is rare, with medulloblastoma and germ-cell tumours most common and gliomas seldom implicated. This report is the first described case of a… read more here.
Keywords: peritoneal cavity; cavity via; glioma; midline glioma ... See more keywords
H3K27-altered diffuse midline glioma: a paradigm shifting opportunity in direct delivery of targeted therapeutics
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DOI: 10.1080/14728222.2023.2177531
Abstract: ABSTRACT Introduction Despite much progress, the prognosis for H3K27-altered diffuse midline glioma (DMG), previously known as diffuse intrinsic pontine glioma when located in the brainstem, remains dark and dismal. Areas covered A wealth of research… read more here.
Keywords: diffuse midline; h3k27 altered; altered diffuse; midline glioma ... See more keywords
THER-05. GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION
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DOI: 10.1093/neuonc/noaa222.855
Abstract: Abstract BACKGROUND H3 K27M-mutant diffuse midline glioma (DMG) is invariably lethal. Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses, in particular, are uniquely tropic for… read more here.
Keywords: midline glioma; antigen; diffuse midline;
The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies
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DOI: 10.1093/neuonc/noac117
Abstract: Abstract Diffuse midline glioma (DMG), including those of the brainstem (diffuse intrinsic pontine glioma), are pediatric tumors of the central nervous system (CNS). Recognized as the most lethal of all childhood cancers, palliative radiotherapy remains… read more here.
Keywords: dmg; diffuse midline; development; midline glioma ... See more keywords
Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma
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DOI: 10.1136/bcr-2019-231424
Abstract: We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI… read more here.
Keywords: survival patient; midline glioma; diffuse midline; prolonged survival ... See more keywords
Abstract 2052: High-plex spatial multiomics of pediatric and adult diffuse midline glioma, H3 K27-altered
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DOI: 10.1158/1538-7445.am2023-2052
Abstract: Background: Diffuse midline glioma (DMG), H3 K27-altered are highly aggressive malignancies of the central nervous system that affect both pediatric and adult populations. The immune layout and genetic changes within the tumor microenvironment associated with… read more here.
Keywords: adult; pediatric adult; diffuse midline; k27 altered ... See more keywords
Abstract 4304: Network-based inference identifies cell state-specific drugs targeting master regulator vulnerabilities in diffuse midline glioma
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DOI: 10.1158/1538-7445.am2023-4304
Abstract: Diffuse Midline Glioma (DMG) are fatal pediatric brain tumors with no therapies. We leveraged network-based methodologies to dissect the heterogeneity of DMG tumors and to discover Master Regulator (MR) proteins representing pharmacologically accessible, mechanistic determinants… read more here.
Keywords: cell; dmg; network; diffuse midline ... See more keywords
Liquid biopsy for pediatric diffuse midline glioma: a review of circulating tumor DNA and cerebrospinal fluid tumor DNA.
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DOI: 10.3171/2019.9.focus19699
Abstract: Diffuse midline glioma (DMG) is a highly malignant childhood tumor with an exceedingly poor prognosis and limited treatment options. The majority of these tumors harbor somatic mutations in genes encoding histone variants. These recurrent mutations… read more here.
Keywords: midline glioma; diffuse midline; tumor dna; circulating tumor ... See more keywords
Development and validation of a machine learning algorithm for predicting diffuse midline glioma, H3 K27-altered, H3 K27 wild-type high-grade glioma, and primary CNS lymphoma of the brain midline in adults.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurosurgery"
DOI: 10.3171/2022.11.jns221544
Abstract: OBJECTIVE Preoperative diagnosis of diffuse midline glioma, H3 K27-altered (DMG-A) and midline high-grade glioma without H3 K27 alteration (DMG-W), as well as midline primary CNS lymphoma (PCNSL) in adults, is challenging but crucial. The aim… read more here.
Keywords: diffuse midline; machine; midline; midline glioma ... See more keywords