Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02142-w
Abstract: Diffuse midline gliomas (DMG) H3 K27M-mutant was introduced in the 2016 WHO Classification of Tumors of the Central Nervous System, unifying diffuse intrinsic pontine gliomas (DIPG) and gliomas from the thalamus and spinal cord harboring… read more here.
Keywords: diffuse; midline gliomas; gliomas; diffuse midline ... See more keywords
Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04489-0
Abstract: H3K27M mutant diffuse midline gliomas (DMGs) are considered grade IV irrespective of histological features and have dismal prognosis. We evaluated clinico-pathologic, radiological, and molecular characteristics of DMGs across all ages. One twenty-six DMGs were identified… read more here.
Keywords: midline gliomas; h3k27m; diffuse midline; h3k27m mutation ... See more keywords
Machine Learning-Based Multi-parametric MRI Radiomics for prediction of H3 K27M Mutation in Midline Gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "World neurosurgery"
DOI: 10.1016/j.wneu.2021.03.135
Abstract: PURPOSE H3 K27M mutation in gliomas has prognostic implications. Previous MRI studies have reported variable rates of tumoral enhancement, necrotic changes and peritumoral edema in H3 K27M-mutant gliomas, with no distinguishing imaging features compared to… read more here.
Keywords: mri; midline gliomas; mutation; k27m mutation ... See more keywords
Immunotherapy approaches for the treatment of diffuse midline gliomas
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DOI: 10.1080/2162402x.2022.2124058
Abstract: ABSTRACT Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall survival is less than 12 months with a… read more here.
Keywords: diffuse midline; treatment; midline gliomas; diffuse ... See more keywords
NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab016
Abstract: Diffuse midline gliomas (DMGs) are incurable pediatric tumors with extraordinarily limited treatment options. Decades of clinical trials combining conventional chemotherapies with radiation therapy have failed to improve these outcomes, demonstrating the need to identify and… read more here.
Keywords: ntrk fusions; midline gliomas; gliomas; diffuse midline ... See more keywords
DIPG-47. HISTONE MUTATIONS ENHANCE RAS MEDIATED ERK5 GROWTH SIGNALING IN DIFFUSE MIDLINE GLIOMAS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.093
Abstract: Abstract Diffuse midline gliomas (DMGs) are incurable brain tumors with an aggressive onset. Apart from irradiation, there are currently no effective therapies available for patients with DMG, who have a median survival time of less… read more here.
Keywords: growth; midline gliomas; diffuse midline;
HGG-16. DISSECTING THE EFFECT OF ATM DELETION ON RADIOSENSITIVITY IN DIFFUSE MIDLINE GLIOMAS WITH H3K27M MUTATION
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab090.082
Abstract: Diffuse midline gliomas (DMGs) are responsible for a large proportion of childhood brain tumor deaths. Currently, radiation therapy is thought to be one of the most effective treatment options, but more than 90% of children… read more here.
Keywords: h3k27m; diffuse midline; dmgs; midline gliomas ... See more keywords
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac041
Abstract: BACKGROUND Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not… read more here.
Keywords: cell; diffuse midline; cell lineage; midline gliomas ... See more keywords
Diffuse Midline Gliomas: Closer to a Cure?
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DOI: 10.1093/neuros/nyx390
Abstract: Diffuse Midline Gliomas: Closer to a Cure? Diffuse midline gliomas (DMGs) are known to be one of the most unforgiving cancers. Many times these cancers attack children at the prime of their youth. The median… read more here.
Keywords: gliomas closer; midline gliomas; diffuse midline;
Prediction of H3K27M mutation status of diffuse midline gliomas using MRI features
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DOI: 10.1111/jon.12905
Abstract: Presurgical prediction of H3K27M mutation in diffuse midline gliomas (DMGs) on MRI is desirable. The purpose of this study is to elaborate conventional MRI (cMRI) features of H3K27M‐mutant DMGs and identify features that could discriminate… read more here.
Keywords: prediction h3k27m; h3k27m mutation; midline gliomas; diffuse midline ... See more keywords
Abstract 1561: Preclinical examination of PLK1 inhibitors for the treatment of diffuse midline gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1561
Abstract: Diffuse Midline Gliomas (DMGs) are devastating and incurable pediatric brain tumours. DMGs are characterised by epigenetic aberrations in the form of histone modifications, coupled with mitotic abnormalities, which together drive a stem-like transcriptional cell state… read more here.
Keywords: plk1; midline gliomas; plk1 inhibitors; diffuse midline ... See more keywords