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   Articles with "midline gliomas" as a keyword



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Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

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recommendations! Published in 2020 at "Acta Neuropathologica"

DOI: 10.1007/s00401-020-02142-w

Abstract: Diffuse midline gliomas (DMG) H3 K27M-mutant was introduced in the 2016 WHO Classification of Tumors of the Central Nervous System, unifying diffuse intrinsic pontine gliomas (DIPG) and gliomas from the thalamus and spinal cord harboring… read more here.

Keywords: diffuse; midline gliomas; gliomas; diffuse midline ... See more keywords
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Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?

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recommendations! Published in 2020 at "Neurological Sciences"

DOI: 10.1007/s10072-020-04489-0

Abstract: H3K27M mutant diffuse midline gliomas (DMGs) are considered grade IV irrespective of histological features and have dismal prognosis. We evaluated clinico-pathologic, radiological, and molecular characteristics of DMGs across all ages. One twenty-six DMGs were identified… read more here.

Keywords: midline gliomas; h3k27m; diffuse midline; h3k27m mutation ... See more keywords

National trends in the treatment of adult diffuse midline gliomas: a rare clinical scenario

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recommendations! Published in 2024 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-024-04663-w

Abstract: Diffuse midline gliomas (DMG) include all midline gliomas with a point mutation to the histone H3 gene resulting in the substitution of a lysine with a methionine (K27M). These tumors are classified as World Health… read more here.

Keywords: diffuse midline; adult; midline gliomas;
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Machine Learning-Based Multi-parametric MRI Radiomics for prediction of H3 K27M Mutation in Midline Gliomas.

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recommendations! Published in 2021 at "World neurosurgery"

DOI: 10.1016/j.wneu.2021.03.135

Abstract: PURPOSE H3 K27M mutation in gliomas has prognostic implications. Previous MRI studies have reported variable rates of tumoral enhancement, necrotic changes and peritumoral edema in H3 K27M-mutant gliomas, with no distinguishing imaging features compared to… read more here.

Keywords: mri; midline gliomas; mutation; k27m mutation ... See more keywords

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

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recommendations! Published in 2024 at "Nature"

DOI: 10.1038/s41586-024-08171-9

Abstract: H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models1. Arm A of Phase I trial no. NCT04196413 (ref. 2) administered… read more here.

Keywords: gd2 cart; gd2; diffuse midline; midline gliomas ... See more keywords

Immunotherapy approaches for the treatment of diffuse midline gliomas

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recommendations! Published in 2022 at "Oncoimmunology"

DOI: 10.1080/2162402x.2022.2124058

Abstract: ABSTRACT Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall survival is less than 12 months with a… read more here.

Keywords: diffuse midline; treatment; midline gliomas; diffuse ... See more keywords
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NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas.

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recommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"

DOI: 10.1093/jnen/nlab016

Abstract: Diffuse midline gliomas (DMGs) are incurable pediatric tumors with extraordinarily limited treatment options. Decades of clinical trials combining conventional chemotherapies with radiation therapy have failed to improve these outcomes, demonstrating the need to identify and… read more here.

Keywords: ntrk fusions; midline gliomas; gliomas; diffuse midline ... See more keywords

DIPG-47. HISTONE MUTATIONS ENHANCE RAS MEDIATED ERK5 GROWTH SIGNALING IN DIFFUSE MIDLINE GLIOMAS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.093

Abstract: Abstract Diffuse midline gliomas (DMGs) are incurable brain tumors with an aggressive onset. Apart from irradiation, there are currently no effective therapies available for patients with DMG, who have a median survival time of less… read more here.

Keywords: growth; midline gliomas; diffuse midline;

HGG-16. DISSECTING THE EFFECT OF ATM DELETION ON RADIOSENSITIVITY IN DIFFUSE MIDLINE GLIOMAS WITH H3K27M MUTATION

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recommendations! Published in 2021 at "Neuro-oncology"

DOI: 10.1093/neuonc/noab090.082

Abstract: Diffuse midline gliomas (DMGs) are responsible for a large proportion of childhood brain tumor deaths. Currently, radiation therapy is thought to be one of the most effective treatment options, but more than 90% of children… read more here.

Keywords: h3k27m; diffuse midline; dmgs; midline gliomas ... See more keywords

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.

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recommendations! Published in 2022 at "Neuro-oncology"

DOI: 10.1093/neuonc/noac041

Abstract: BACKGROUND Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not… read more here.

Keywords: cell; diffuse midline; cell lineage; midline gliomas ... See more keywords

DIPG-29. PHENOTYPIC SCREENS IDENTIFY GENETIC REGULATORS OF NANOPARTICLE DELIVERY IN DIFFUSE MIDLINE GLIOMAS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.082

Abstract: Abstract BACKGROUND Diffuse midline gliomas (DMGs) are a universally fatal pediatric brain tumor with a median survival of 12 months. There is a dire need to develop novel treatment strategies for these patients. Nanomedicine harbors… read more here.

Keywords: regulators nanoparticle; diffuse midline; genetic regulators; midline gliomas ... See more keywords