Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial
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DOI: 10.1007/s00134-020-06216-x
Abstract: ICU discharge is often delayed by a requirement for intravenous vasopressor medications to maintain normotension. We hypothesised that the administration of midodrine, an oral α1-adrenergic agonist, as adjunct to standard treatment shortens the duration of… read more here.
Keywords: midodrine; time vasopressor; vasopressor discontinuation; time ... See more keywords
High-dose midodrine is not effective for treatment of persistent hypotension in the intensive care unit
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DOI: 10.1007/s00134-020-06333-7
Abstract: We are thankful to Riker and Gagnon for their comment [1] on our recently published MIDAS trial [2]. Many intensivists would like to use midodrine to facilitate discharge from the intensive care unit (ICU) in… read more here.
Keywords: midodrine; dose midodrine; high dose; intensive care ... See more keywords
New stability chiral RP-HPLC method for degradation products determination in midodrine hydrochloride.
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DOI: 10.1080/03639045.2021.1908340
Abstract: Enantiomeric resolution of the drug and complete separation from its degradation products were successfully achieved on a PAK IG-3 (150 × 4.6 mm i.d, 3 µm particle size) column, using UV detector at a wavelength of 290 nm, with mobile… read more here.
Keywords: midodrine; degradation; degradation products; method ... See more keywords
Trends in Use of Midodrine in the ICU: A Single-Center Retrospective Case Series
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DOI: 10.1097/ccm.0000000000003121
Abstract: Objectives: Midodrine is an oral alpha-agonist approved for orthostatic hypotension. The use of midodrine as a vasopressor sparing agent has steadily increased in the ICU despite limited evidence for its safety in that setting. We… read more here.
Keywords: midodrine; single center; use midodrine; case ... See more keywords