Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region
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DOI: 10.1002/1873-3468.14505
Abstract: Ack1 is a proto‐oncogenic tyrosine kinase with homology to the tumour suppressor Mig6, an inhibitor of the epidermal growth factor receptor (EGFR). The residues critical for binding of Mig6 to EGFR are conserved within the… read more here.
Keywords: kinase; mig6; activity; homology ... See more keywords
Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS‐induced endotoxemia
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DOI: 10.1002/jcp.26488
Abstract: Epithelial growth factor receptor (EGFR), a tyrosine kinase receptor, plays a critical role in lipopolysaccharide (LPS)‐induced endotoxemia. Meanwhile, EGFR signaling is regulated by multiple feedback regulators, including mitogen‐inducible gene 6 protein (Mig6). However, as an… read more here.
Keywords: lps induced; production; induced endotoxemia; activation ... See more keywords
Abstract 3516: RUNX1 controls EGFR signaling pathway in non-small cell lung cancer cells
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DOI: 10.1158/1538-7445.am2017-3516
Abstract: Epidermal growth factor receptor (EGFR) is a promising target for anticancer therapy for non-small lung cancer (NSCLC). Mitogen-inducible gene 6 (Mig6) is known to be a negative feedback regulator of EGFR. Mig6 inhibits EGFR kinase… read more here.
Keywords: egfr; runx1; pathway; mig6 ... See more keywords
Mig6 Is Required for Pancreas Development in Zebrafish
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DOI: 10.2337/db18-2122-p
Abstract: Strategies to promote β cell neogenesis could be used to restore functional β cell mass in both type 1 and type 2 diabetes. Here we examine the role of mitogen-inducible gene 6 ( mig6, a.k.a.… read more here.
Keywords: mig6 required; pancreas development; role; mig6 ... See more keywords