Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1438800
Abstract: ABSTRACT Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short serum half-life and high dose-related toxicities limit its clinical efficacy. Here, we constructed heterodimeric immunoglobulin Fc-fused mouse IL12 (mIL12)… read more here.
Keywords: il12; cd8 cells; mil12; memory cd8 ... See more keywords
Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1034774
Abstract: Tumor-targeting antibody (Ab)-fused cytokines, referred to as immunocytokines, are designed to increase antitumor efficacy and reduce toxicity through the tumor-directed delivery of cytokines. However, the poor localization and intratumoral penetration of immunocytokines, especially in solid… read more here.
Keywords: antitumor; mil12; hct; intratumoral penetration ... See more keywords
Enhancing Tumor Immunity with IL-12 and PD-1 Blockade: A Strategy for Inducing Robust Central Memory T Cell Responses in Resistant Cancer Model
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DOI: 10.3390/antib13040094
Abstract: Background: Although immune checkpoint inhibitors (ICIs) have demonstrated efficacy in treating advanced cancers, their therapeutic success remains limited for many patients, with initial responders often experiencing resistance and relapse. Interleukin-12 (IL-12) is a powerful cytokine… read more here.
Keywords: cell; tumor; mil12; central memory ... See more keywords