Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.
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DOI: 10.1021/acs.orglett.9b00557
Abstract: The synthesis of several 1,1-disubstituted trifluoromethyl-cyclopropanes (TFCPs), known as tert-butyl bioisosteres, has been achieved from the reaction between trifluoromethylalkenes and unstabilized sulfonium ylides in yields of ≤97%. This method offers practical access to this cyclopropyl… read more here.
Keywords: diazo free; trifluoromethyl cyclopropanes; sulfonium ylides; mild diazo ... See more keywords