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   Articles with "mild hypothermia" as a keyword



Neuroprotective effects of mild hypothermia against traumatic brain injury by the involvement of the Nrf2/ARE pathway

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recommendations! Published in 2022 at "Brain and Behavior"

DOI: 10.1002/brb3.2686

Abstract: Traumatic brain injury (TBI) is the leading cause of death and disability worldwide. Mild hypothermia (32–35°C) has been found to show neuroprotective effects against TBI. However, the specific mechanism is still elusive. In the current… read more here.

Keywords: traumatic brain; neuroprotective effects; mild hypothermia; brain ... See more keywords

Urine Proteomic Signatures of Mild Hypothermia Treatment in Cerebral Ischemia–Reperfusion Injury in Rats

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recommendations! Published in 2024 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-024-01483-4

Abstract: Mild hypothermia (MH) is an effective measure to alleviate cerebral ischemia–reperfusion (I/R) injury. However, the underlying biological mechanisms remain unclear. This study set out to investigate dynamic changes in urinary proteome due to MH in… read more here.

Keywords: treatment; ischemia reperfusion; cerebral ischemia; reperfusion injury ... See more keywords

Effects of Mild Hypothermia on Cerebral Large and Small Microvessels Blood Flow in a Porcine Model of Cardiac Arrest

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recommendations! Published in 2017 at "Neurocritical Care"

DOI: 10.1007/s12028-017-0395-6

Abstract: BackgroundThe effect of mild hypothermia (MH) on microcirculation after resuscitation from cardiac arrest is controversial. The aim of this study was to determine whether MH improves or aggravates the disturbance of cerebral microcirculation.MethodsTwenty domestic male… read more here.

Keywords: blood flow; hypothermia; mild hypothermia; group ... See more keywords

CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP+

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recommendations! Published in 2020 at "Molecular Neurobiology"

DOI: 10.1007/s12035-020-02014-0

Abstract: Mild hypothermia has promising effects in the treatment of acute brain insults and also affects cell cycle progression. Mitochondrial dynamics, fusion and fission, are changed along with the cell cycle and disrupted in neurodegenerative diseases,… read more here.

Keywords: hypothermia; mild hypothermia; fission; cdk4 ... See more keywords

Expression regulation of cold-inducible protein RBM3 by FAK/Src signaling for neuroprotection against rotenone under mild hypothermia.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.11.105

Abstract: Mild hypothermia is a well-established technique for alleviating neurological injuries in clinical surgery. RNA-binding protein motif 3 (RBM3) has been identified as a crucial factor in mediating hypothermic neuroprotection, providing its induction as a promising… read more here.

Keywords: rbm3; hypothermia; mild hypothermia; fak src ... See more keywords

Therapeutic time window and regulation of autophagy by mild hypothermia after intracerebral hemorrhage in rats

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.04.005

Abstract: Although recent studies have shown that mild hypothermia has neuroprotective effects on intracerebral hemorrhage (ICH), the therapeutic time window of the therapy and the role of autophagy as a potential neuroprotective mechanism remain unclear. This… read more here.

Keywords: time window; therapeutic time; mild hypothermia; intracerebral hemorrhage ... See more keywords

Mild hypothermia protects hippocampal neurons against oxygen‐glucose deprivation/reperfusion‐induced injury by improving lysosomal function and autophagic flux

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recommendations! Published in 2017 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2017.06.010

Abstract: ABSTRACT Mild hypothermia has been proven to be useful to treat brain ischemia/reperfusion injury. However, the underlying mechanisms have not yet been fully elucidated. The present study was undertaken to determine whether mild hypothermia protects… read more here.

Keywords: hippocampal neurons; mild hypothermia; hypothermia; autophagic flux ... See more keywords

Recombinant High-Density Lipoprotein Boosts the Therapeutic Efficacy of Mild Hypothermia in Traumatic Brain Injury.

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recommendations! Published in 2022 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.2c02940

Abstract: Traumatic brain injury (TBI) leads to neuropsychiatric symptoms and increased risk of neurodegenerative disorders. Mild hypothermia is commonly used in patients suffering from severe TBI. However, its effect for long-term protection is limited, mostly because… read more here.

Keywords: mild hypothermia; tbi; brain; efficacy ... See more keywords
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Cardioprotective effect of combination therapy by mild hypothermia and local or remote ischemic preconditioning in isolated rat hearts

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-020-79449-x

Abstract: A multitargeted strategy to treat the consequences of ischemia and reperfusion (IR) injury in acute myocardial infarction may add cardioprotection beyond reperfusion therapy alone. We investigated the cardioprotective effect of mild hypothermia combined with local… read more here.

Keywords: hypothermia; mild hypothermia; ischemic preconditioning; cardioprotective effect ... See more keywords

Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-21388-6

Abstract: Therapeutic hypothermia (TH) has demonstrated neuroprotection in instances of cardiac arrest and neonatal hypoxia/ischemia but faces different challenges in application to stroke due to the activation of cold defense mechanisms in conscious patients. This study… read more here.

Keywords: core; mild hypothermia; vagal afferents; trpv1 agonists ... See more keywords

Mild hypothermia attenuates ischemia/reperfusion injury - insights from serial non-invasive pressure-volume loops.

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recommendations! Published in 2023 at "Cardiovascular research"

DOI: 10.1093/cvr/cvad028

Abstract: BACKGROUND Mild hypothermia, 32-35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries, but human trials have been ambiguous. To elucidate the cardioprotective mechanisms of mild hypothermia, we analyzed cardiac performance in a porcine… read more here.

Keywords: mild hypothermia; reperfusion; volume; pressure ... See more keywords