Neuroprotective effects of mild hypothermia against traumatic brain injury by the involvement of the Nrf2/ARE pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2686
Abstract: Traumatic brain injury (TBI) is the leading cause of death and disability worldwide. Mild hypothermia (32–35°C) has been found to show neuroprotective effects against TBI. However, the specific mechanism is still elusive. In the current… read more here.
Keywords: traumatic brain; neuroprotective effects; mild hypothermia; brain ... See more keywords
Effects of Mild Hypothermia on Cerebral Large and Small Microvessels Blood Flow in a Porcine Model of Cardiac Arrest
Sign Up to like & getrecommendations! Published in 2017 at "Neurocritical Care"
DOI: 10.1007/s12028-017-0395-6
Abstract: BackgroundThe effect of mild hypothermia (MH) on microcirculation after resuscitation from cardiac arrest is controversial. The aim of this study was to determine whether MH improves or aggravates the disturbance of cerebral microcirculation.MethodsTwenty domestic male… read more here.
Keywords: blood flow; hypothermia; mild hypothermia; group ... See more keywords
CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP+
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02014-0
Abstract: Mild hypothermia has promising effects in the treatment of acute brain insults and also affects cell cycle progression. Mitochondrial dynamics, fusion and fission, are changed along with the cell cycle and disrupted in neurodegenerative diseases,… read more here.
Keywords: hypothermia; mild hypothermia; fission; cdk4 ... See more keywords
Expression regulation of cold-inducible protein RBM3 by FAK/Src signaling for neuroprotection against rotenone under mild hypothermia.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.105
Abstract: Mild hypothermia is a well-established technique for alleviating neurological injuries in clinical surgery. RNA-binding protein motif 3 (RBM3) has been identified as a crucial factor in mediating hypothermic neuroprotection, providing its induction as a promising… read more here.
Keywords: rbm3; hypothermia; mild hypothermia; fak src ... See more keywords
Therapeutic time window and regulation of autophagy by mild hypothermia after intracerebral hemorrhage in rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.04.005
Abstract: Although recent studies have shown that mild hypothermia has neuroprotective effects on intracerebral hemorrhage (ICH), the therapeutic time window of the therapy and the role of autophagy as a potential neuroprotective mechanism remain unclear. This… read more here.
Keywords: time window; therapeutic time; mild hypothermia; intracerebral hemorrhage ... See more keywords
Mild hypothermia protects hippocampal neurons against oxygen‐glucose deprivation/reperfusion‐induced injury by improving lysosomal function and autophagic flux
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.06.010
Abstract: ABSTRACT Mild hypothermia has been proven to be useful to treat brain ischemia/reperfusion injury. However, the underlying mechanisms have not yet been fully elucidated. The present study was undertaken to determine whether mild hypothermia protects… read more here.
Keywords: hippocampal neurons; mild hypothermia; hypothermia; autophagic flux ... See more keywords
Recombinant High-Density Lipoprotein Boosts the Therapeutic Efficacy of Mild Hypothermia in Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c02940
Abstract: Traumatic brain injury (TBI) leads to neuropsychiatric symptoms and increased risk of neurodegenerative disorders. Mild hypothermia is commonly used in patients suffering from severe TBI. However, its effect for long-term protection is limited, mostly because… read more here.
Keywords: mild hypothermia; tbi; brain; efficacy ... See more keywords
Cardioprotective effect of combination therapy by mild hypothermia and local or remote ischemic preconditioning in isolated rat hearts
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-79449-x
Abstract: A multitargeted strategy to treat the consequences of ischemia and reperfusion (IR) injury in acute myocardial infarction may add cardioprotection beyond reperfusion therapy alone. We investigated the cardioprotective effect of mild hypothermia combined with local… read more here.
Keywords: hypothermia; mild hypothermia; ischemic preconditioning; cardioprotective effect ... See more keywords
Mild hypothermia attenuates ischemia/reperfusion injury - insights from serial non-invasive pressure-volume loops.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad028
Abstract: BACKGROUND Mild hypothermia, 32-35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries, but human trials have been ambiguous. To elucidate the cardioprotective mechanisms of mild hypothermia, we analyzed cardiac performance in a porcine… read more here.
Keywords: mild hypothermia; reperfusion; volume; pressure ... See more keywords
Effects of mild hypothermia on serum HMGB1 of brain-dead donors and its impact on kidney transplantation recipients
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000020425
Abstract: Supplemental Digital Content is available in the text Abstract Investigate the effect of mild hypothermia on serum inflammatory factor HMGB1 of brain-dead donors, and its significance for renal transplantation recipients. In our hospital between January… read more here.
Keywords: hypothermia; serum; mild hypothermia; hypothermia group ... See more keywords
Mild Hypothermia Attenuates Hepatic Ischemia–Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/5849794
Abstract: Hepatic ischemia–reperfusion (IR) injury is a clinical issue that can result in poor outcome and lacks effective therapies at present. Mild hypothermia (32–35°C) is a physiotherapy that has been reported to significantly alleviate IR injury,… read more here.
Keywords: jak2 stat3; mild hypothermia; fao; ischemia reperfusion ... See more keywords