A Mild Silica Gel Promoted Synthesis and Initial Functional Study of Tetrapyridyl Tetrahydropyrrolopyrrolones.
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DOI: 10.1021/acs.orglett.2c02095
Abstract: A one-pot strategy with yields up to 82% was reported to generate 2-(pyridin-2-yl)-2-(3,3a,6-tris(5-pyridin-2-yl)-5-oxohexahydropyrrolo[3,2-b] pyrrol-2(1H)-ylidene)acetonitrile 1a and its derivatives 1b-d. Silica gel promoted quantitative conversion from stable intermediate to 1a within 30 min at room temperature.… read more here.
Keywords: mild silica; initial functional; gel promoted; synthesis initial ... See more keywords