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   Articles with "mild stress" as a keyword



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Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress

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recommendations! Published in 2019 at "Psychopharmacology"

DOI: 10.1007/s00213-019-05257-5

Abstract: Rationale and objectivePaeoniflorin has been reported to exhibit antidepressant-like effects in several animal model depression; and it also exerts a neuroprotective effect. In the present study, we investigated the effects of paeoniflorin administration on depression-like… read more here.

Keywords: subjected chronic; paeoniflorin; chronic unpredictable; mice subjected ... See more keywords
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Covid-19 and the next outbreak: decreasing frailty by using mild stress?

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recommendations! Published in 2021 at "Biogerontology"

DOI: 10.1007/s10522-021-09930-1

Abstract: The coronavirus disease 2019 (Covid-19) has resulted in many deaths, particularly of very old or obese people. These people are at risk to die in the event of an outbreak, like under one-year old babies… read more here.

Keywords: covid next; next outbreak; covid; frailty ... See more keywords
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Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression

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recommendations! Published in 2019 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2019.112053

Abstract: Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways affected by chronic stress… read more here.

Keywords: chronic unpredictable; stress; coupled dopaminergic; unpredictable mild ... See more keywords
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Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats

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recommendations! Published in 2020 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2020.112710

Abstract: 20 (S)-protopanaxadiol (PPD) possesses a variety of biological activities, including antioxidant, antifatigue and anti-inflammatory properties. This study was aimed to investigate the antidepressant-like effects of PPD and potential mechanisms in rats exposed to chronic unpredictable… read more here.

Keywords: chronic unpredictable; like behaviour; depressive like; unpredictable mild ... See more keywords
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Mild stress culture conditions promote neurite outgrowth of retinal explants from postnatal mice

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recommendations! Published in 2020 at "Brain Research"

DOI: 10.1016/j.brainres.2020.147050

Abstract: The axons of retinal ganglion cells (RGCs) in adult mammals fail to regenerate after injury. It has been suggested that some extrinsic factors, such as neural activity, may promote the regeneration process. The present study… read more here.

Keywords: neural activity; postnatal mice; retinal explants; neurite outgrowth ... See more keywords
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Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression

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recommendations! Published in 2017 at "Brain Research Bulletin"

DOI: 10.1016/j.brainresbull.2017.08.009

Abstract: Major depression is a common neuropsychiatric disease with high lifetime prevalence and high incidence of suicide. This study aimed to evaluate the antidepressant effects of ginsenoside Rg2 in mice, and the possible mechanism was also… read more here.

Keywords: effects ginsenoside; like effects; chronic mild; mild stress ... See more keywords
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Electroacupuncture alleviated the depression-like behavior by regulating FGF2 and astrocytes in the hippocampus of rats with chronic unpredictable mild stress

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recommendations! Published in 2021 at "Brain Research Bulletin"

DOI: 10.1016/j.brainresbull.2021.01.005

Abstract: Studies have shown that basic fibroblast growth factor (FGF2) is a neurotrophic factor associated with depression. Electroacupuncture (EA) has been shown to be an effective treatment for depression. In the current study, we observed the… read more here.

Keywords: depression; fgf2 astrocytes; chronic unpredictable; group ... See more keywords
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Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters.

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recommendations! Published in 2019 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2019.172725

Abstract: Dehydrocorydaline, is an active alkaloid compound in Corydalis yanhusuo W. T. Wang. We found dehydrocorydaline induced antidepressant-like effects in a chronic unpredictable mild stress mouse model, but the exact mechanisms have not been addressed. We… read more here.

Keywords: chronic unpredictable; dehydrocorydaline; effect; unpredictable mild ... See more keywords
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Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model

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recommendations! Published in 2019 at "Heliyon"

DOI: 10.1016/j.heliyon.2019.e01600

Abstract: Nicotine is the most common and highly addictive drug of abuse, associated with several life-threatening diseases and high mortality. Nicotine abuse is the concerted effort to feel reward and fight depression in depressed individuals. The… read more here.

Keywords: depression; chronic unpredictable; unpredictable mild; sonic hedgehog ... See more keywords

Electroacupuncture relieves depression-like symptoms in rats exposed to chronic unpredictable mild stress by activating ERK signaling pathway

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recommendations! Published in 2017 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.01.060

Abstract: Electroacupuncture (EA) has been shown to alleviate the symptoms associated with major depressive disorder; however, the underlying mechanisms remain unclear. While the mainstay treatment for depression are pharmacological agents that modulate serotonergic and/or noradrenergic activity… read more here.

Keywords: depression; chronic unpredictable; erk; unpredictable mild ... See more keywords

Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress

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recommendations! Published in 2018 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.09.046

Abstract: Accumulating studies have shown that a traditional Chinese decoction Chaihu-Shugan-San produced the antidepressant-like effects in rodents including in perimenopausal. Previous studies and our preliminary study indicated that saikosaponin A, one of the main constituents of… read more here.

Keywords: chronic unpredictable; saikosaponin; test; unpredictable mild ... See more keywords