Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis
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DOI: 10.1038/s41408-019-0202-z
Abstract: Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer and activator of transcription (STAT) proteins in the presence of Myeloproliferative Leukemia Virus (MPL) and induce… read more here.
Keywords: mpl; human calr; mild thrombocytosis; mice ... See more keywords