Porcine milk exosome miRNAs protect intestinal epithelial cells against deoxynivalenol-induced damage.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113898
Abstract: Porcine milk exosomes play an important role in mother-infant communication. Deoxynivalenol (DON) is a toxin which causes serious damage to the animal intestinal mucosa. Our previous study showed porcine milk exosomes facilitate mice intestine development,… read more here.
Keywords: porcine milk; milk exosomes; induced damage; damage ... See more keywords
High-quality milk exosomes as oral drug delivery system.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121126
Abstract: Many drugs must be administered intravenously instead of oral administration due to their poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as high as tens of billions of… read more here.
Keywords: milk; milk exosomes; drug delivery; high quality ... See more keywords
Milk exosomes - Natural nanoparticles for siRNA delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.02.011
Abstract: Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery.… read more here.
Keywords: sirna delivery; milk exosomes; delivery; cancer ... See more keywords
Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate research"
DOI: 10.1016/j.carres.2020.108032
Abstract: Milk exosomes (mExo), similar to cell-derived exosomes, are emerging as promising nanocarriers for delivery of therapeutic molecules such as chemical drugs and siRNA, due to the excellent biocompatibility and low-cost production from bovine milk. However,… read more here.
Keywords: milk; milk exosomes; delivery; tumor specific ... See more keywords
Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2021.104338
Abstract: Exosomes are membranous vesicles of endocytic origin, recently been considered as major players in cell-cell communication. Milk is highly complex, and diverse biocomponents provide adequate nutrition, transfer immunity, and promote adequate neonate development. Milk exosomes… read more here.
Keywords: milk; milk exosomes; mature milk; proteome ... See more keywords
Drug Loading and Functional Efficacy of Cow, Buffalo, and Goat Milk-Derived Exosomes: A Comparative Study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00182
Abstract: Quite recently, milk exosomes have been recognized as efficient drug delivery systems owing to their biocompatibility and easy availability for scale-up technologies. However, there are no reports of comparative studies with regards to drug delivery… read more here.
Keywords: milk; milk exosomes; drug; cow buffalo ... See more keywords
Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm01497d
Abstract: Bovine milk-derived exosomes have recently emerged as a promising nano-vehicle for the encapsulation and delivery of macromolecular biotherapeutics. Here we engineer high purity bovine milk exosomes (mExo) with modular surface tunability for oral delivery of… read more here.
Keywords: oral delivery; delivery; milk exosomes; delivery sirna ... See more keywords
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2021.2023699
Abstract: Abstract The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. The impaired angiogenesis phase during diabetic wound healing partly contributes to the pathological process. MicroRNA (miRNA) is an… read more here.
Keywords: wound healing; diabetic wound; angiogenesis; delivery ... See more keywords
A complete proteomic profile of human and bovine milk exosomes by liquid chromatography mass spectrometry
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2021.1980389
Abstract: ABSTRACT Background The present study investigates the proteomic content of milk-derived exosomes. A detailed description of the content of milk exosomes is essential to improve our understanding of the various components of milk and their… read more here.
Keywords: milk; milk exosomes; mass spectrometry; bovine milk ... See more keywords
Microbial mRNAs in Bovine Milk Exosomes Are Bioavailable in Humans and Mice and Increase Survival of Mice Challenged with Influenza A (OR12-07-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz049.or12-07-19
Abstract: Objectives Exosomes are natural nanoparticles that facilitate cell-to-cell communication by transferring RNAs from donor to recipient cells. Previous studies focused on microRNA cargos and disregarded mRNAs. Exosomes and RNA cargos may be absorbed from milk.… read more here.
Keywords: microbial mrnas; milk; bovine milk; bioavailable humans ... See more keywords
Yak milk-derived exosome alleviates lipopolysaccharide-induced intestinal inflammation by inhibiting PI3K/AKT/C3 pathway activation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dairy science"
DOI: 10.3168/jds.2021-20175
Abstract: Intestinal epithelial cells (IEC) are important parts of the mucosal barrier, whose function can be impaired upon various injury factors such as lipopolysaccharide. Although food-derived exosomes are preventable against intestinal barrier injuries, there have been… read more here.
Keywords: milk; milk exosomes; intestinal inflammation; yak milk ... See more keywords