Nanosuspensions of a poorly soluble investigational molecule ODM-106: impact of milling bead diameter and stabilizer concentration.
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DOI: 10.1016/j.ijpharm.2020.119636
Abstract: Aqueous solubility of a drug substance is an important attribute affecting oral bioavailability. Nanonization, particle size reduction to submicron level, is an elegant approach to improve drug solubility and dissolution by increasing the surface energy,… read more here.
Keywords: bead diameter; investigational molecule; diameter stabilizer; milling bead ... See more keywords