Parts-per-Million Detection of Trace Crystal Forms Using AF-PTIR Microscopy.
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DOI: 10.1021/acs.analchem.2c02358
Abstract: Autofluorescence-detected photothermal mid-infrared (AF-PTIR) microscopy was shown to enable parts-per-million detection of α-indomethacin impurity in γ-indomethacin samples. Subtle differences in the photothermal response of the UV-autofluorescence of two indomethacin crystal polymorphs were used for sub-micron… read more here.
Keywords: ptir microscopy; million detection; microscopy; per million ... See more keywords