Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49096-y
Abstract: Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part of these patients, pain may… read more here.
Keywords: irritable bowel; visceral hypersensitivity; bowel syndrome; miltefosine ... See more keywords
Resolution of Acanthamoeba Keratitis with Adjunctive Use of Oral Miltefosine
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2019.1695853
Abstract: ABSTRACT Purpose: To report a series of cases demonstrating the resolution of Acanthamoeba keratitis (AK) with adjunctive use of oral miltefosine. Methods: Retrospective case series. Results: The first case was a 27-year-old female who presented… read more here.
Keywords: resolution acanthamoeba; keratitis adjunctive; oral miltefosine; acanthamoeba keratitis ... See more keywords
Miltefosine Reduces the Cytolytic Activity and Virulence of Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01409-18
Abstract: Stagnation in antimicrobial development has led to a serious threat to public health because some Acinetobacter baumannii infections have become untreatable. New therapeutics with alternative mechanisms of action to combat A. baumannii are therefore necessary… read more here.
Keywords: virulence; miltefosine; acinetobacter baumannii; activity ... See more keywords
Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02507-18
Abstract: Host immune responses are pivotal for the successful treatment of the leishmaniases, a spectrum of infections caused by Leishmania parasites. Previous studies speculated that augmenting cytokines associated with a type 1 T-helper cell (Th1) response… read more here.
Keywords: host mediated; treatment; immunomodulation; miltefosine ... See more keywords
Treatment of Schistosoma mansoni with miltefosine in vitro enhances serological recognition of defined worm surface antigens
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005853
Abstract: Background Miltefosine, an anti-cancer drug that has been successfully repositioned for treatment of Leishmania infections, has recently also shown promising effects against Schistosoma spp targeting all life cycle stages of the parasite. The current study… read more here.
Keywords: treatment; surface; worm surface; miltefosine ... See more keywords
Impavido attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice.
Sign Up to like & getrecommendations! Published in 2023 at "iScience"
DOI: 10.2139/ssrn.4201712
Abstract: Impavido (Miltefosine) is an FDA-approved drug for treating leishmaniasis and primary amebic meningoencephalitis. We have shown previously that Miltefosine increased cholesterol release and dampened Nlrp3 inflammasome assembly in macrophages. Here, we show that Miltefosine reduced… read more here.
Keywords: inflammation; gut microbiota; miltefosine fed; atherosclerosis ... See more keywords
Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.954144
Abstract: Visceral leishmaniasis (VL), caused by Leishmania infantum, is an oft-fatal neglected tropical disease. In the absence of an effective vaccine, the control of leishmaniasis relies exclusively on chemotherapy. Due to the lack of established molecular/genetic… read more here.
Keywords: amphotericin; resistance; drug; approach ... See more keywords
In Vitro Antifungal Susceptibility Profile of Miltefosine against a Collection of Azole and Echinocandins Resistant Fusarium Strains
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8070709
Abstract: Fusarium species are filamentous fungi that cause a variety of infections in humans. Because they are commonly resistant to many antifungal drugs currently available in clinical settings, research into alternative targets in fungal cells and… read more here.
Keywords: antifungal susceptibility; vitro antifungal; susceptibility profile; fusarium ... See more keywords
Sporothrix spp. Biofilms Impact in the Zoonotic Transmission Route: Feline Claws Associated Biofilms, Itraconazole Tolerance, and Potential Repurposing for Miltefosine
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11020206
Abstract: Sporotrichosis is the most prevalent subcutaneous mycosis globally, and it is typically caused by direct inoculation of the soil saprophytic fungus Sporothrix spp. into the patients’ skin. However, sporotrichosis has an important zoonotic transmission route… read more here.
Keywords: miltefosine; transmission route; sporothrix spp; zoonotic transmission ... See more keywords
Investigation of in vitro Efficacy of Miltefosine on Chronic Cutaneous Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2022 at "Turkiye parazitolojii dergisi"
DOI: 10.4274/tpd.galenos.2022.85856
Abstract: OBJECTIVE Leishmaniasis is the second deadliest parasitic disease in the World Health Organisation's list of neglected diseases, following malaria. Cutaneous leishmaniasis (CL) is the most common form of the disease and it is one of… read more here.
Keywords: vitro efficacy; efficacy; cutaneous leishmaniasis; efficacy miltefosine ... See more keywords