IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
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DOI: 10.1016/j.exphem.2019.06.411
Abstract: Precursor-B acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy. Relapsed disease has a poor prognosis despite improved outcomes with tyrosine kinase inhibitors (TKIs) and immunotherapeutic approaches such as CAR-T cells. Targeting cell survival with… read more here.
Keywords: bh3 mimetic; acute lymphoblastic; bh3; lymphoblastic leukemia ... See more keywords