Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT).
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213777120
Abstract: The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to generate mature bioactive cytokine and gasdermin D… read more here.
Keywords: human keratinocytes; dsdna mimetic; activate nlrp1; poly ... See more keywords
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental neuroscience"
DOI: 10.1159/000530185
Abstract: Maternal immune activation (MIA) can result from a variety of maternal inflammatory factors, including metabolic disorders, nutritional deficits, infections, and psychosocial stress. MIA has been consistently recognized as a major risk factor for neurodevelopmental disorders,… read more here.
Keywords: maternal immune; mia; mimetic poly; viral mimetic ... See more keywords